A study on prescribing pattern of cephalosporins utilization and its compliance towards the hospital antibiotic policy in surgery ward of a tertiary care teaching hospital in India

Joy, Shinu; Panda, Bijoy Kumar; Banerjee, Jayant Kumar; Soman, Nikki

doi:10.18203/2349-2902.isj20194413

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…One study was conducted by Thakur P, et al, 2012 [13] they also found that amikacin was found to be most susceptible antibiotic in the study and found to be most effective and susceptible antibiotic. In another study conducted by Soman N et al [14] reported that increased cephalosporin prescribing practice, which may result in antibiotic resistance, and there is need of strict monitoring of cephalosporin antibiotic usage in hospital.…”

Section: Discussionmentioning

confidence: 99%

“…Urine samples showed a culture positivity of 40% with 65 bacterial isolates. E. coli (34) was mostly isolated.Pus samples showed a culture positivity of 33% with 53 bacterial isolates and Pseudomonas Aeruginosa (14) was the prominent isolate from the pus samples and blood samples showed a culture positivity of 14% with 23 bacterial. Sputum samples showed a culture positivity of (8%).…”

Section: Distribution Of Bacterial Isolates and Culturementioning

confidence: 95%

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Development of Antibiogram for Evaluation of Antibiotic Resistance Pattern in Tertiary Care Teaching Hospital: a Cross Sectional Study

Dikkatwar

Mansuri

Chaudhari

et al. 2020

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Background: Antimicrobial resistance threatens the effective prevention and treatment of increasing number of cases of antibiotic resistance worldwide. So there is need of effective implementation of the treatment strategy to rationalize the antimicrobial use in the treatment of infectious disease. So the present study is aims to attempts to find the local antibiotic resistance, various microorganism responsible for infection using the antibiogram in the tertiary care teaching hospital.Methods: A cross-sectional study was carried out to check the Antibiotic resistance pattern based on the inclusion and exclusion criteria at Parul Sevasharam Hospital, Vadodara, Gujarat. Total 150 patients were included in study, culture sensitivity test and bacterial identification was done as per the microbiology department standard guidelines. Patient’s data regarding to demographic details, culture sensitivity test results and prescribed antibiotics was collected for 6 months’ duration from October 2019 to March 2020. Results: Total 150 samples were collected throughout the study period of six months in the various departments in the hospital. The main finding of our study,greater resistance found in Ceftriaxone (78%), Meropenem (71%), Azithromycin (66%), linezolid (66%), Amoxicillin+clavulanic acid (63%), Ciprofloxacin (56%) of patients in these antibiotics. Greater susceptibility was found in Clindamycin (75%), Amikacin (65%), Piperacilline+tazobactum (62%), Cefoperazone (48%), ciprofloxacin (44%) of the patients. During our study, 20 antibiotics were commonly prescribed out of which ceftriaxone was most commonly prescribed in our study and which was found to most resistant in patient population. The most common bacteria identified in our study was gram negative bacteria in that E. Coli, Pseudomonas Aeruginosa and KlebseillaPneuminiae was most commonly isolated.Conclusion: This study shows that there is increasing cases of antibiotic resistance identified in the hospital. Ceftriaxone is found to be most resistant in our study. So there is need of effective treatment strategies and use of antibiogram to find out the local antibiotic resistance pattern and to develop antibiotic policy for the safe use of antibiotic which is helpful for to reduce the antibiotic resistance.

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Section: Discussionmentioning

confidence: 99%

Section: Distribution Of Bacterial Isolates and Culturementioning

confidence: 95%

Development of Antibiogram for Evaluation of Antibiotic Resistance Pattern in Tertiary Care Teaching Hospital: a Cross Sectional Study

Dikkatwar

Mansuri

Chaudhari

et al. 2020

Preprint

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Quantity and quality profiles of antibiotics pre, on, and post surgery in a hospital setting

et al. 2021

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Background Providing proper antibiotics is undoubtedly crucial to prevent infections during surgery. Objective This study set out to evaluate the medication administration in antibiotic prophylaxis using both quantitative and qualitative methods. Setting The study employed a retrospective design and observed patients who underwent surgical procedures during hospitalization at a private hospital in Indonesia within the period of January-June 2019. Methods The data obtained were evaluated quantitatively and qualitatively; and analyzed descriptively. The quantitative evaluation used the defined daily dose (DDD) per 100 bed-days. The qualitative evaluation was expressed as the percentage of antibiotic suitability based on antibiotic administration, i.e. (1) type; (2) timing; (3) dosage; (4) duration; and (5) route. Main outcome measure Suitability of antibiotic prophylaxis in a hospital setting. Results There were 164 prescriptions recorded from 20 types of surgical procedures, of which the most common was cholecystectomy (23 patients, 14%). Most antibiotics were administered 61-120 min before the incision time (55 patients, 37%), and had a duration of more than 24 h (119 patients, 80%). The total DDD per 100 bed-days for pre-, on-, and post-surgery antibiotic use were 44.2, 33.3, and 66.7 respectively. The suitability profiles of the antibiotics used according to the Antibiotic Use Guideline for Hospital (2018) were as follows: 26.3% right type, 52.9% right time, 24.8% right dosage, 19.1% right duration, 91.8% right route, while according to American Society of Health-System Pharmacists Therapeutic Guidelines (2014) there were 17.6% right type, 53.4% right time, 16.4% right dosage, 19.1% right duration, and 96.6% right route. Conclusion Ceftriaxone was the first-choice prophylactic antibiotic administered in this Indonesian hospital. The data indicate a considerable non-compliance with local and international guidelines. Keywords Antibiotic prophylaxis • DDD per 100 bed-days • Inappropriate prescriptions • Surgery Impacts on practice• Evaluating antibiotic prophylaxis is useful for assessing the possibility of inappropriate antibiotic use. • Surgeons tend to prescribe prophylactic antibiotics for all types of surgery despite the absence of prerequisites for some of them.• Frequent inappropriate use of antibiotics can increase the cost of treatment and antibiotic resistance in patients. • Increasing adherence to guidelines and the use of appropriate prophylactic antibiotics are important points in prevention of surgical site infection and control of microbial resistance. • To increase adherence, training is needed to normalize antibiotic selection in accordance with international and local guidelines.

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Evaluation of antibiotic consumption and compliance to hospital antibiotic policy in the surgery, orthopedics and gynecology wards of a tertiary care hospital

Thomas

Kumar

Johnson

et al. 2022

Clinical Epidemiology and Global Health

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To evaluate antibiotic consumption and compliance to hospital antibiotic policy in the surgery, orthopedics and gynecology wards of a tertiary care hospital. Methods: A prospective observational study was conducted over eight months on adult inpatients prescribed with antibiotics. Data were collected using a predesigned antibiotic form and evaluated using Defined Daily Dose per 100 bed-days. Antibiotics prescribed were classified using World Health Organization Access, Watch and Reserve classification (WHO AWaRe) and assessed for compliance to the hospital antibiotic policy which is in accordance with the National Treatment Guidelines for Antimicrobial use in Infectious Diseases (version 1.0.2016). Results: Out of 2653 patients enrolled, 44.3% were males and 55.7% were females. The antibiotic usage rate was 29%. Cephalosporins were the most frequently prescribed class of antibiotics. The top three antibiotics prescribed were cefuroxime, metronidazole, and ceftriaxone. Classification of antibiotics using WHO AWaRe policy showed that 36% of antibiotics were prescribed from the Access group and 53% from the Watch group. The use of antibiotic combinations from the not recommended group of AWaRe was also observed. Total compliance observed towards the hospital's antibiotic policy was 77.7%. The most common reason for non-compliance to hospital policy was inappropriate duration of antibiotic therapy. Conclusions: The use of watch group of antibiotics over access group due to concerns of antimicrobial resistance shows the need for local adaptation of WHO AWaRe classification. Despite good adherence to the hospital's antibiotic policy, extended duration of antibiotic therapy requires special attention. Further optimization of antibiotic use can be achieved by timely revision and implementation of hospital antibiotic policy.

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A study on prescribing pattern of cephalosporins utilization and its compliance towards the hospital antibiotic policy in surgery ward of a tertiary care teaching hospital in India

Cited by 5 publications

References 22 publications

Development of Antibiogram for Evaluation of Antibiotic Resistance Pattern in Tertiary Care Teaching Hospital: a Cross Sectional Study

Development of Antibiogram for Evaluation of Antibiotic Resistance Pattern in Tertiary Care Teaching Hospital: a Cross Sectional Study

Quantity and quality profiles of antibiotics pre, on, and post surgery in a hospital setting

Evaluation of antibiotic consumption and compliance to hospital antibiotic policy in the surgery, orthopedics and gynecology wards of a tertiary care hospital

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