A Study on Pre-Emptive Analgesic Effect of Intravenous Paracetamol in Functional Endoscopic Sinus Surgeries: A Randomized, Double-Blinded Clinical Study

Preventive Acetaminophen Reduces Postoperative Opioid Consumption, Vomiting, and Pain Scores After Surgery

“…[20][21][22][23][24][25][26] All studies were randomized controlled trials (Table 1). Accurate risk of bias assessment was difficult because of poor reporting in most of the trials.…”

“…21,24 Mean duration of surgery ranged from 60 to 135 minutes. The initial dose of acetaminophen was given 15 to 30 minutes before induction of anesthesia in 5 studies, [20][21][22]24,26 30 minutes preoperatively in 1 study, 23 and 10 minutes before incision in 1 study. 25 …”

“…Time to first analgesic request was reported in 4 studies. [22][23][24][25] These studies showed a beneficial effect in the preventive acetaminophen group, with patients requesting their first analgesic 12.48 minutes later (95% CI, 1.39-23.58 minutes) than the postincision group. Statistical heterogeneity was considerable (I 2 = 89%; P < 0.001).…”

“…Four studies 20,22,24,25 reported the incidence of postoperative nausea, and 5 studies reported the incidence of postoperative vomiting. 20,22,[24][25][26] One study 26 included both nausea and vomiting requiring antiemetic treatment and was included in the vomiting outcome.…”

“…20,22,[24][25][26] One study 26 included both nausea and vomiting requiring antiemetic treatment and was included in the vomiting outcome. There was no significant difference in the risk of postoperative nausea, with an RR of 0.78 (95% CI, 0.43-1.41).…”