A Study on Molecular Mechanisms of Terahertz Radiation Interaction with Biopolymers Based on the Example of Bovine Serum Albumin

Немова, Е. Ф.; Черкасова, О. П.; Николаев, Н. А.; Dultseva, G.G.

doi:10.1134/s000635092003015x

Cited by 4 publications

(2 citation statements)

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“… 211 , 212 In Ref. 213 , BSA was exposed, for 60 min, to the pulsed THz radiation with the 0.2- to 1.5-THz spectral bandwidth and the peak irradiance of

(or the average irradiance of

), whereas the sample was in the form of thin films on a crystalline

substrate. Then, BSA was dissolved in water and brought into interaction with some adsorbates with high biological relevance, i.e., oxygen, ozone, and nitric oxide.…”

Section: Terahertz Exposure Of Biological Objects With Different Levels Of Organizationmentioning

confidence: 99%

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Cellular effects of terahertz waves

et al. 2021

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. Significance: An increasing interest in the area of biological effects at exposure of tissues and cells to the terahertz (THz) radiation is driven by a rapid progress in THz biophotonics, observed during the past decades. Despite the attractiveness of THz technology for medical diagnosis and therapy, there is still quite limited knowledge about safe limits of THz exposure. Different modes of THz exposure of tissues and cells, including continuous-wave versus pulsed radiation, various powers, and number and duration of exposure cycles, ought to be systematically studied. Aim: We provide an overview of recent research results in the area of biological effects at exposure of tissues and cells to THz waves. Approach: We start with a brief overview of general features of the THz-wave–tissue interactions, as well as modern THz emitters, with an emphasis on those that are reliable for studying the biological effects of THz waves. Then, we consider three levels of biological system organization, at which the exposure effects are considered: (i) solutions of biological molecules; (ii) cultures of cells, individual cells, and cell structures; and (iii) entire organs or organisms; special attention is devoted to the cellular level. We distinguish thermal and nonthermal mechanisms of THz-wave–cell interactions and discuss a problem of adequate estimation of the THz biological effects’ specificity. The problem of experimental data reproducibility, caused by rareness of the THz experimental setups and an absence of unitary protocols, is also considered. Results: The summarized data demonstrate the current stage of the research activity and knowledge about the THz exposure on living objects. Conclusions: This review helps the biomedical optics community to summarize up-to-date knowledge in the area of cell exposure to THz radiation, and paves the ways for the development of THz safety standards and THz therapeutic applications.

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“… 211 , 212 In Ref. 213 , BSA was exposed, for 60 min, to the pulsed THz radiation with the 0.2- to 1.5-THz spectral bandwidth and the peak irradiance of

(or the average irradiance of

), whereas the sample was in the form of thin films on a crystalline

substrate. Then, BSA was dissolved in water and brought into interaction with some adsorbates with high biological relevance, i.e., oxygen, ozone, and nitric oxide.…”

Section: Terahertz Exposure Of Biological Objects With Different Levels Of Organizationmentioning

confidence: 99%

“…THz irradiation excites definite collective rotational motions, which partially eliminate steric hindrance for the adsorption of molecular oxygen on the functional groups of BSA. 213 …”

Section: Terahertz Exposure Of Biological Objects With Different Levels Of Organizationmentioning

confidence: 99%

Cellular effects of terahertz waves

et al. 2021

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Effect of terahertz radiation on intermolecular interactions of albumin under aerobic and anaerobic conditions

Nemova

Dultseva

Николаев

et al. 2021

J. Phys.: Conf. Ser.

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The effect of THz radiation on coupling between albumin molecules under aerobic and anaerobic conditions is assessed through an EPR-quantified procedure. Rearrangements induced by terahertz radiation are found to affect the hydrogen bonding network causing an increase in the rate of bimolecular interactions. Molecular mechanism of the observed effect is considered involving the interactions between the functional groups of albumin molecules. Irradiation causes conformational changes in albumin molecules, which involves changes in the steric states of molecules. These rearrangements hinder or simplify the adsorption of specific agents on the reactive sites of albumin molecules.

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