Micro/nanofluids are the recent alternative solutions for cooling lubrication that can be defined as the fluids containing microparticles or nanoparticles, which own superior lubrication and cooling characteristics. For these reasons, they have gained significant attention in industrial applications, such as automotive, machining, and biomedical industries. In this chapter, the authors mainly present the recent progress and applications of nanofluids in machining processes, as well as some initial researches about microfluids. Nanofluids provide an excellent media in cutting zone for enhancing the thermal conductivity and tribological characteristics. Therefore, they help to enhance the cutting performance by reducing the coefficient of friction, cutting temperature tool wear, and improving the surface quality. Moreover, the application of nanoparticles in vegetable oils, which are inherently nontoxic as well as biodegradable, gives them superior lubrication properties suitable for MQL application, especially for difficult-to-cut materials. The novel green technology definitely brings out many new solutions in machining practice.