A Study on Infertility of Males Infected with &amp;lt;i&amp;gt;Mycoplasma hominis&amp;lt;/i&amp;gt; with Reference to Sperm Morphology

Al-Jebouri, Mohemid M.; Mohamed, Ayad Abdullah

doi:10.4236/ojpathology.2021.111002

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Undoubtedly, urogenital infections play an important role in this (Enwuru & Iwalokun, 2016;Grande, 2018;Al-Jebouri & Mohamed, 2021). The structure of pathogens of infectious diseases has undergone significant evolution in recent years.…”

Section: Introduсtionmentioning

confidence: 99%

Сondition of urogenital tract microbiotes and pro- and antioxidant system in male azoospermia

Vorobets

Melnyk

Коваленко

et al. 2021

Regul. Mech. Biosyst.

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Over the past 20 years, there has been a clear trend to increase in the number of infertile men in Ukraine, their percentage reaches 50% in infertile couples. There is a significant percentage of male infertility caused by azoospermia – the lack of sperm in the ejaculate. In male infertility, azoospermia is found in 10–15% of patients, among other forms of pathospermia. Given the ambiguity of ideas about the etiology, pathogenesis and treatment and diagnostic approaches for various types of infertility, it remains important to clarify the relationship of urogenital infections with the regulatory systems of cells, including the state of the pro- and antioxidant system and the search for additional markers. 119 patients with various forms of azoospermia were examined. All patients underwent the following studies: spermogram, infectious screening, inhibin B, lipid peroxidation, activity of enzymes of the glutathione antioxidant system in sperm plasma and blood serum. Infectious screening included analysis of urethral secretions, bacteriological examination of sperm or prostate secretion, assessment of the species and quantitative composition of the microflora of the male urogenital tract. According to the results of spermogram and other diagnostic methods, a non-obstructive form of azoospermia was detected in 69 patients. In obstructive azoospermia, ejaculate as such was absent. It is suggested that inhibin B may be an important medical diagnostic test for azoospermia. As a result of the conducted researches the importance of determining the concentration of inhibin B as a marker of azoospermia was demonstrated and a negative correlation of moderate strength between the content of inhibin B and testosterone level in the plasma of men with non-obstructive azoospermia was revealed. It was found that Ureaplasma pervum and Ureaplasma urealyticum infect the male genitourinary system to the greatest extent among a number of microorganisms, both in non-obstructive and obstructive forms of azoospermia. Enterococcus faecalis is more pronounced in the sperm fluid in the non-obstructive form of azoospermia and prostate secreton in the obstructive form of azoospermia. In the non-obstructive form of azoospermia in the seminal plasma and serum, the processes of lipid peroxidation intensify, the concentration of reduced glutathione decreases and the activities of the enzymes of the glutathione antioxidant system (glutathione peroxidase and glutathione transferase) decrease. It can be considered that an important diagnostic test for the nonobstructive form of azoospermia is the ratio of reduced glutathione to oxidized glutathione in sperm plasma.

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Section: Introduсtionmentioning

confidence: 99%

Сondition of urogenital tract microbiotes and pro- and antioxidant system in male azoospermia

Vorobets

Melnyk

Коваленко

et al. 2021

Regul. Mech. Biosyst.

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“…Although, according to some researchers, Mycoplasma hominis is an opportunistic pathogen, justifying this by the possibility of isolating it from clinically healthy individuals, as well as asymptomatic clinical course of urogenital mycoplasmosis [25]. However, it should be noted that a lot of work has been done to study the eff ect of Mycoplasma hominis on sperm morphology and motility [26], the ability to respond to acrosomal reactions, and the eff ect on sperm nuclear integrity [27]. Moreover, microorganisms increase in size as the infection progresses, as well as attached mycoplasmas undergo morphological changes from bulb-like shape to spherical shapes.…”

mentioning

confidence: 99%

Urogenital Infection as a Factor of Development of Male Infertility

et al. 2023

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To date, according to statistics, in Ukraine there is an increase in the number of infertile marriages. Many studies have emphasized the male factor of infertility Often, male infertility is the result of a previous infectious disease or an acute genital inflammation. Microorganisms that infect sperm usually persist in the urinary tract as a monoinfection or form associations. Microorganisms in biofilms are able to acquire new, not yet studied, properties. Persistence of pathogens in the urogenital tract of men triggers several mechanisms of the pathological action on sperm, the first of which is the infectious factor, directly related to the adhesion and resulting in a complete or partial decrease in the mobility and deformation of sperm. On the other hand, the development of the inflammatory process as a trigger of an immune response directed simultaneously against the infectious agent and the affected sperm. The increase in the number of leukocytes at the site of inflammation activates the secretion of biological substances which also have a damaging effect on sperm. The generalized data allow drawing a conclusion about the significant influence of opportunistic and pathogenic microorganisms as part of associations or monoinfection on the morphofunctional state of spermatozoa.

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Multi-locus sequence typing of geographically and temporally diverse strains of Mycoplasma hominis

Boujemaa,

Suri,

Kaur

2024

Diagnostic Microbiology and Infectious Disease

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A Study on Infertility of Males Infected with <i>Mycoplasma hominis</i> with Reference to Sperm Morphology

Cited by 4 publications

References 35 publications

Сondition of urogenital tract microbiotes and pro- and antioxidant system in male azoospermia

Сondition of urogenital tract microbiotes and pro- and antioxidant system in male azoospermia

Urogenital Infection as a Factor of Development of Male Infertility

Multi-locus sequence typing of geographically and temporally diverse strains of Mycoplasma hominis

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