A Study on Impact of BPA in the Adipose Tissue Dysfunction (Adiposopathy) in Asian Indian Type 2 Diabetes Mellitus Subjects

Abstract

A surge to increase the production via usage of chemicals at both industrial and agricultural arena has forced humans to be routinely and imprudently exposed to a wide variety of endocrine disrupting chemicals. The overall aim of the study was to evaluate possible relation that might exist between bisphenol-A (BPA) and the adipose tissue hormones, and further impact on adiposopathy.In the present study, the role of BPA, an ''endocrine disruptor'' with respect to adiposopathy was evaluated in type 2 diabetes mellitus patients. For the study, 150 healthy control subjects and 150 newly diagnosed diabetes patients were recruited. Fasting venous blood samples was analyzed for several biochemical parameters such as serum glucose, lipid profile, insulin, adiponectin, leptin, TNF-a, IL-6, IL-1, free fatty acid. Concentrations of BPA were also measured both in control and diabetic subjects. Serum BPA concentration was found to be significantly higher in diabetic subjects in comparison to the control subjects. Levels of BPA were found to be positively correlated with BMI and WC in diabetic subjects. Also, it was found to be positively correlated with leptin and negatively correlated with adiponectin in diabetic subjects. Therefore, the current study suggested more deleterious effect of BPA on diabetes and its pathophysiology.

Human Exposure to Bisphenols, Parabens, and Benzophenones, and Its Relationship with the Inflammatory Response: A Systematic Review

“…Table 1 exhibits the main characteristics of the 20 studies [ 43 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 ]. All included studies were published in the last 15 years (2008–2023).…”

“…Studies were carried out in Asian (45.0%), American (30.0%) and European countries (20.0%). The reporting quality was classified as high in 15 studies (75.0%), while five studies (25.0%) had medium reporting quality [ 62 , 66 , 71 , 72 , 73 ]. The risk of bias was classified as very high in two studies [ 58 , 71 ], high in six studies [ 59 , 62 , 65 , 66 , 70 , 72 ], with some concerns in three studies [ 56 , 61 , 68 ], and low in nine studies [ 43 , 57 , 60 , 62 , 63 , 67 , 69 , 73 , 74 ] ( Figure 2 ).…”

“…The reporting quality was classified as high in 15 studies (75.0%), while five studies (25.0%) had medium reporting quality [ 62 , 66 , 71 , 72 , 73 ]. The risk of bias was classified as very high in two studies [ 58 , 71 ], high in six studies [ 59 , 62 , 65 , 66 , 70 , 72 ], with some concerns in three studies [ 56 , 61 , 68 ], and low in nine studies [ 43 , 57 , 60 , 62 , 63 , 67 , 69 , 73 , 74 ] ( Figure 2 ). Taken together, the higher concerns were due to confounding, the measurement of the exposure, and missing data, as shown in Figure 3 .…”

Bisfenol a y efectos de disrupción endocrina en humanos y animales: Revisión sistemática

“…El efecto obesógeno de BPA es otro de los efectos de disrupción endocrina encontrado en esta revisión, el cual fue caracterizado por la ganancia de grasa (>IMC) en niños expuestos en la etapa prenatal (Choi et al, 2020;Li et al, 2017;Zhang et al, 2017). Además, este se relacionó con la susceptibilidad al desarrollo de diabetes tipo 2 y alteraciones en las hormonas tiroideas (Adoamnei et al, 2018;Derakhshan et al, 2019;Jain et al, 2020;(Li et al, 2019;Soundararajan et al, 2019). Al igual que los efectos en la reproducción, la ganancia de peso inducida por el BPA es un tema de gran interés en la comunidad científica, dados los altos índices mundiales de obesidad presentada en niños y adultos.…”

The Current Findings on the Impact of Prenatal BPA Exposure on Metabolic Parameters: In Vivo and Epidemiological Evidence

“…BPA is a well-known endocrine disruptor that has obesogenic effects. According to epidemiological, in vitro, and in vivo studies, BPA has many effects on human health, such as cardiovascular diseases [12,13], obesity [14], T2DM [15,16], decreasing neurogenesis, negatively impacting the brain and behaviour, impairing learning, contributing to memory performance impairment [17,18], and affecting fertility [19]. A large body of evidence links BPA to adverse health effects on metabolism through epidemiological, in vivo, and in vitro studies.…”