A Study on Hematological Spectrum in Patients with Alcoholic Liver Cirrhosis

Aggarwal, Himanshu; Rao, Upendar; Singla, Suhas; Dabas, Geeta

doi:10.1016/j.jceh.2015.07.036

Cited by 2 publications

(2 citation statements)

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“…In the present study, administration of C. molmol to normal rats did not affect the hematological and coagulation system parameters, whereas hyperammonemic rats exhibited anemia, leukocytosis, thrombocytopenia, and prolonged PT and aPTT. Hematological abnormalities occur frequently in liver disease conditions [ 78 ]. In support of our findings, Kalaitzakis et al [ 79 ] have demonstrated that HE is related to anemia in liver transplant candidates with cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, hyperammonemic rats showed leukocytosis. Accordingly, Choi et al [ 82 ] reported mild leukocytosis in hyperammonemic patients with ornithine carbamoyltransferase deficiency and Aggarwal et al [ 78 ] demonstrated a significant association of leukocytosis with HE. Interestingly, C. molmol prevented all hematological alterations in hyperammonemic rats.…”

Section: Discussionmentioning

confidence: 99%

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Commiphora molmol Modulates Glutamate‐Nitric Oxide‐cGMP and Nrf2/ARE/HO‐1 Pathways and Attenuates Oxidative Stress and Hematological Alterations in Hyperammonemic Rats

Mahmoud

Alqahtani

Othman

et al. 2017

Oxidative Medicine and Cellular Longevity

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Hyperammonemia is a serious complication of liver disease and may lead to encephalopathy and death. This study investigated the effects of Commiphora molmol resin on oxidative stress, inflammation, and hematological alterations in ammonium chloride- (NH4Cl-) induced hyperammonemic rats, with an emphasis on the glutamate-NO-cGMP and Nrf2/ARE/HO-1 signaling pathways. Rats received NH4Cl and C. molmol for 8 weeks. NH4Cl-induced rats showed significant increase in blood ammonia, liver function markers, and tumor necrosis factor-alpha (TNF-α). Concurrent supplementation of C. molmol significantly decreased circulating ammonia, liver function markers, and TNF-α in hyperammonemic rats. C. molmol suppressed lipid peroxidation and nitric oxide and enhanced the antioxidant defenses in the liver, kidney, and cerebrum of hyperammonemic rats. C. molmol significantly upregulated Nrf2 and HO-1 and decreased glutamine and nitric oxide synthase, soluble guanylate cyclase, and Na+/K+-ATPase expression in the cerebrum of NH4Cl-induced hyperammonemic rats. Hyperammonemia was also associated with hematological and coagulation system alterations. These alterations were reversed by C. molmol. Our findings demonstrated that C. molmol attenuates ammonia-induced liver injury, oxidative stress, inflammation, and hematological alterations. This study points to the modulatory effect of C. molmol on glutamate-NO-cGMP and Nrf2/ARE/HO-1 pathways in hyperammonemia. Therefore, C. molmol might be a promising protective agent against hyperammonemia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%