The rapid global increase in Special Economic Zones (SEZs) raises concerns regarding potential impacts on the environment, especially water use intensity, an increased risk of natural disasters, and an elevated greenhouse gas (GHG) emissions. However, studies examining these impacts are limited. Therefore, the aim of this paper is to examine the influence of SEZ development factors on flooding, water scarcity, and GHG emissions using Tak SEZ in Thailand as a case study. A Driver-Pressure-State-Impact-Response (DPSIR) framework, together with structural equation modeling (SEM) through the partial least squares (PLS) approach, has been used to examine the interrelationships between these factors. The results revealed that economic, industrial, and urban development are key drivers associated with flooding, water scarcity, and GHG emissions in the zone. The increased population density, water consumption, waste generation, and vehicular traffic are all significantly put pressure on climate change impacts. The integration of DPSIR framework together with PLS-SEM technique to explore the relationship among multiple sustainability indicators contributes to the existing sustainability assessment methodology. Future research can utilize the presented indicators to identify potential factors for the evaluation of other types of development zones that have a variety of socio-economic activities.