A Study on Expression of P53 in Surface Epithelial Ovarian Tumours

Sreeja, T.T.; Chandrasekhar, Srinivasan; Magar, S. Lokesh Rao; Durga, K.; Rani, Hephzibah; Anil, Sandhya

doi:10.5958/2347-6206.2015.00004.7

Cited by 2 publications

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“…Ki-67 expression-Ki-67 expression was highest in malignant cases 84.61% followed by borderline 77.77% and benign tumors 4.61%. Ki 67 positivity was maximum for endometrioid carcinoma (100%) and borderline serous tumors (100%) followed by serous carcinoma (95%), borderline mucinous tumors (85.71%), mucinous carcinoma (40%) and benign serous tumors (8.33%) (table no.1) Sreeja T.T et al, [11] Pooja S. Naik et al, [12] Mary T. Sylvia et al [13] and Jha et al [14] reported maximum incidence of ovarian tumor in the age group of 30-50 year, while Ranjana Banyopadhyay [15] reported maximum number of cases in the age group of 35 year. In present study, we also found the similar results with maximum cases in the age group of 31-40 year followed by 41-50 year age group.…”

Section: Issn-2321-127xmentioning

confidence: 97%

“…Sreeja T.T. et al, [11] Pooja S.Naik et al [12] and Jha R. et al [14] reported that majority of cases (64.46%,74.54% and 83.90% respectively) were benign in their studies although number of cases varies in morphological spectrum of the epithelial ovarian tumors. Mary T. Sylvia et al [13] reported minimum 28.33% of benign cases in there study.…”

Section: Issn-2321-127xmentioning

confidence: 99%

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Expression of estrogen receptor, progesterone receptor and KI 67 in epithelial ovarian tumors and their histopathological correlation

2017

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Introduction: Expression of ER, PR and Ki 67 in epithelial ovarian tumors and their histopathological correlation analyzed by immunohistochemistry. Methods: This study was conducted on 60 ovarian specimens received in Department of Pathology, Gandhi Medical College, Bhopal for ovarian tumors from 1 st January 2012-31 st august 2016. Results: The expression of ER was more in malignant tumor 21/26 than borderline 5/9 and benign tumors 5/25. The PR expression was more in benign tumors 14/25 than malignant 13/26 and borderline 2/9 tumors. The Ki67 expression was more in malignant tumors 22/26 than borderline 7/9 and benign 1/25 tumors. Conclusion: In our study ER and Ki-67 positivity was maximally seen in malignant cases. This shows that ER was enhanced in ovarian carcinoma and Ki67 was proliferative marker. PR expression was maximally seen in benign tumors. This showed protective role of PR marker in ovarian carcinoma.

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Section: Issn-2321-127xmentioning

confidence: 97%

Section: Issn-2321-127xmentioning

confidence: 99%

Expression of estrogen receptor, progesterone receptor and KI 67 in epithelial ovarian tumors and their histopathological correlation

2017

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Clinicopathological study of epithelial neoplasms of ovary with special reference to the expression of P53 and Her2/neu in epithelial carcinoma

Sen¹,

Chatterjee

2022

IJPO

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Ovarian cancer represents 30% of all cancers of female genital tract. An accurate histopathological diagnosis of ovarian tumours is essential for their management and the outcome of therapy.Clinicopathological study of ovarian epithelial neoplasms and to study the expression of p53 and Her2/neu in epithelial carcinoma of ovary and their association with the histological grade. An observational descriptive type of study in a tertiary care hospital in Eastern India. 72 cases diagnosed as ovarian epithelial neoplasms in the department of Pathology, CNMC&H Kolkata during the study period of January, 2019 to December, 2020 were studied. Specimens were processed routinely. Immunohistochemistry was done following standard protocol.Statistical analysis was done using SPSS (version 21.0, Chicago inc., Chicago, Illinois, USA) software. 57 cases were benign followed by 14 malignant and 1 borderline case. Majority of the tumours were serous type (71.4%) followed by mucinous (27.2%) and seromucinous (1.4%). P53 expression was noted in 50% of the epithelial ovarian carcinoma and 85.7% of the high grade serous carcinoma. Her2/neu expression was noted in 21.4% of epithelial ovarian carcinoma cases. p53 expression was more in serous carcinoma and the expression of p53 was associated with higher grade of serous carcinoma. Her2/neu expression was more in serous carcinoma. There was no significant association between Her2/neu expression and histological grade and a larger population based study is needed for further evaluation.

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A Study on Expression of P53 in Surface Epithelial Ovarian Tumours

Cited by 2 publications

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Expression of estrogen receptor, progesterone receptor and KI 67 in epithelial ovarian tumors and their histopathological correlation

Expression of estrogen receptor, progesterone receptor and KI 67 in epithelial ovarian tumors and their histopathological correlation

Clinicopathological study of epithelial neoplasms of ovary with special reference to the expression of P53 and Her2/neu in epithelial carcinoma

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