A study on clinico-etiological profile of chronic liver disease in children between 1year to 14 years of age

Abstract

Introduction: Chronic liver diseases (CLD) account for 1 to 5% of paediatric ward admissions and upto 20% of ward mortality in our country. Now a day Indian childhood cirrhosis is a rarity, whereas diseases likechronic hepatitis, Wilsons disease and biliary atresia are diagnosed with increasing frequency and therefore became relatively important forms of paediatric liver disease. Methodology: The study was done to determine the clinico-etiological profile of chronic liver disease in children 1 year to 14 years. This is a prospective case-controlled study done over a period of two years. Various clinical, biochemical and radiographic parameters pertaining to chronic liver disease were studied. Results: About40 cases were studied. CLD was found to be prevalent in 5-10 years of age group. Male were more affected than female. Jaundice was the most common presenting feature. Hepatomegaly, Ascitis, Splenomegaly were thecommonest presenting signs.Conclusion: CLD is not uncommon condition in children. It constitutes 18.34% of the patients of the with liver disease in our region. Wilson's disease was the most common aetiology apart from idiopathic which constitute 52.5% of the cause.

Diagnostic value of serum cytokeratin‐18 in children with chronic liver disease

“…Chronic liver disease (CLD) implies long‐lasting irreversible damage in the liver‐related structure . CLD refers to a wide spectrum of disorders characterised by ongoing liver damage with potential for progression to cirrhosis or end‐stage liver disease . Hepatic diseases are a common cause of illness and death in children …”