A Study on Clinical and Pathologic Features in Lupus Nephritis with Mainly IgA Deposits and a Literature Review

Liu, Hongyan; Zheng, Yi; Dong, Bao; Yuewu, Lu; Juan, M D de

doi:10.1155/2013/289316

Cited by 10 publications

(5 citation statements)

References 8 publications

(6 reference statements)

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“…Thus, isotype shifting from IgM to IgG in the lung likely exacerbates lupus pathogenesis. IgA AAbs might also have pathogenic roles, particularly in the context of glomerulonephritis [82,83]. While IgA nephropathy is the most common IgA-associated autoimmune disease [18], this isotype has been linked to other autoimmune diseases, including lupus [84][85][86].…”

Section: Discussionmentioning

confidence: 99%

Omega-3 fatty acid intake suppresses induction of diverse autoantibody repertoire by crystalline silica in lupus-prone mice

Rajasinghe

Zhu

et al. 2020

Autoimmunity

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Inhalation of crystalline silica (cSiO 2) in the workplace is etiologically linked to lupus and other autoimmune diseases. Exposing lupus-prone NZBWF1 mice to respirable cSiO 2 unleashes a vicious cycle of inflammation and cell death in the lung that triggers interferon-regulated gene expression, ectopic lymphoid structure (ELS) development, elevation of local and systemic autoantibodies (AAbs), and glomerulonephritis. However, cSiO 2-induced inflammation and onset of autoimmunity can be prevented by inclusion of the x-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) into the diet of these mice. Since cSiO 2 both causes cell death and interferes with efferocytosis, secondary necrosis of residual cell corpses might provide a rich and varied autoantigen (AAg) source in the lung. While it is known that the particle induces anti-nuclear and anti-dsDNA AAbs in NZBWF1 mice, the full extent of the cSiO 2-induced AAb response relative to specificity and isotype is not yet understood. The purpose of this study was to test the hypotheses that cSiO 2 exposure induces a wide spectrum of AAbs in the pulmonary and systemic compartments, and that dietary DHA intervention prevents these changes. Archived tissue fluid samples were obtained from a prior study in which NZBWF1 mice were fed purified isocaloric diets containing no DHA (control) or DHA corresponding calorically to human doses of 2 and 5 g/day. Mice were intranasally instilled with 1 mg cSiO 2 or saline vehicle weekly for 4 weeks, then groups euthanized 1, 5, 9, or 13 weeks post-instillation (PI) of the last cSiO 2 dose. Bronchoalveolar lavage fluid (BALF) and plasma from each time point were subjected to AAb profiling using a microarray containing 122 AAgs. cSiO 2 triggered robust IgG and IgM AAb responses against lupus-associated AAgs, including DNA, histones, ribonucleoprotein, Smith antigen, Ro/SSA, La/SSB, and complement as early as 1 week PI in BALF and 5 weeks PI in plasma, peaking at 9 and 13 weeks PI, respectively. Importantly, cSiO 2 also induced AAbs to AAgs associated with rheumatoid arthritis (collagen II, fibrinogen IV, fibrinogen S, fibronectin, and vimentin), Sj€ ogren's syndrome (a-fodrin), systemic sclerosis (topoisomerase I), vasculitis (MPO and PR3), myositis (Mi-2, TIF1-c, MDA5), autoimmune hepatitis (LC-1), and celiac disease (TTG). cSiO 2 elicited comparable but more modest IgA AAb responses in BALF and plasma. cSiO 2-induced AAb production was strongly associated with time dependent inflammatory/autoimmune gene expression, ELS development, and glomerulonephritis. AAb responses were dose-dependently suppressed by DHA supplementation and negatively correlated with the x-3 index, an erythrocyte biomarker of x-3 content in tissue phospholipids. Taken together, these findings suggest that cSiO 2 exposure elicits a diverse multi-isotype repertoire of AAbs, many of which have been reported in individuals with lupus and other autoimmune diseases. Furthermore, induction of this broad AAb spectrum could be impeded by increasing x-3 tissue content v...

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Section: Discussionmentioning

confidence: 99%

Omega-3 fatty acid intake suppresses induction of diverse autoantibody repertoire by crystalline silica in lupus-prone mice

Rajasinghe

Zhu

et al. 2020

Autoimmunity

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“…Some SLE patients were reported to have nephritis with mainly IgA deposits, which were considered IgAN patients. However this classification remains controversial since many authors believe this feature to be a clinical subtype of SLE [230].…”

Section: Autoantibody Isotypes: Classes And/or Subclasses Mattermentioning

confidence: 99%

Autoantibodies in SLE: Specificities, Isotypes and Receptors

2016

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Systemic Lupus Erythematosus (SLE) is characterized by a wide spectrum of auto-antibodies which recognize several cellular components. The production of these self-reactive antibodies fluctuates during the course of the disease and the involvement of different antibody-secreting cell populations are considered highly relevant for the disease pathogenesis. These cells are developed and stimulated through different ways leading to the secretion of a variety of isotypes, affinities and idiotypes. Each of them has a particular mechanism of action binding to a specific antigen and recognized by distinct receptors. The effector responses triggered lead to a chronic tissue inflammation. DsDNA autoantibodies are the most studied as well as the first in being characterized for its pathogenic role in Lupus nephritis. However, others are of growing interest since they have been associated with other organ-specific damage, such as anti-NMDAR antibodies in neuropsychiatric clinical manifestations or anti-β2GP1 antibodies in vascular symptomatology. In this review, we describe the different auto-antibodies reported to be involved in SLE. How autoantibody isotypes and affinity-binding to their antigen might result in different pathogenic responses is also discussed.

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“…Existen casos reportados de asociación entre LESJ y (11)(12)(13)(14)(15) NIgA, aunque en su mayoría en adultos , reportándose un caso interesante de Lupus (16) monogénico y NIgA en una adolescente de 15 años . En GWAS, se describen los loci que demuestran asociación entre LES e NIgA: CFH, HLA-DRA, HLA- En este caso, la paciente presentó criterios para LESJ a la edad de 13 años, manifestados por artritis, poliserositis, anemia hemolítica autoinmune, leucopenia, ANA positivo, Anti-DNA positivo, c3 y c 4 b a j o s .…”

Section: Discussionunclassified

Nefropatía por IgA en una adolescente con lupus eritematoso sistémico juvenil. Reporte de caso

Basabe

Troche

Pico

et al. 2023

Pediatr (Asunción).

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Introducción: El lupus eritematoso sistémico juvenil (LESJ) es una enfermedad autoinmunitaria, multisistémica, caracterizada por la producción de autoanticuerpos y el desarrollo frecuente de glomerulonefritis mediada por inmunocomplejos. La nefritis lúpica es una complicación frecuente y grave del LESJ, con alta morbilidad, siendo causa de insuficiencia renal terminal en muchos de estos pacientes. La Nefritis por IgA representa la etiología más común en la población general y raramente se asocia con LESJ. Caso clínico: adolescente femenino con LESJ en quien se diagnosticó nefritis no lúpica (nefritis por IgA). Conclusiones: El diagnóstico anatomopatológico es clave para establecer el pronóstico y planificar el tratamiento.

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A Study on Clinical and Pathologic Features in Lupus Nephritis with Mainly IgA Deposits and a Literature Review

Cited by 10 publications

References 8 publications

Omega-3 fatty acid intake suppresses induction of diverse autoantibody repertoire by crystalline silica in lupus-prone mice

Omega-3 fatty acid intake suppresses induction of diverse autoantibody repertoire by crystalline silica in lupus-prone mice

Autoantibodies in SLE: Specificities, Isotypes and Receptors

Nefropatía por IgA en una adolescente con lupus eritematoso sistémico juvenil. Reporte de caso

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