A study on changing trends in the management of Entric fever

Abstract

Aim and Objective: To study the changing profile of enteric fever with reference to clinical features and complications and also study the response of enteric fever to various drugs. Methodology: The present study was carried out of 75 cases of enteric fever and admitted to the paediatric department of Dr VRK Womens hospital and Princess Durru Shehvar Hospital from March 2018 to September 2018, Cases diagnosed as enteric fever. In all cases, a detailed Clinical history, complete physical examination, family history, history of Contact with patient of enteric fever, the type of water supply, post immunisation Status of enteric fever were asked. Only those cases with a rising litre by slide agglutination or Positive tube agglutination more than 1:80 or Positive blood culture reports were included in this study to know the clinical profile. Children between the ages of 0-12 years were selected for the study. Results: 75 cases of enteric fever in children up to 12 years of age formed the study group. 67% were boys and 33% were girls. The youngest patient in our study was 9 months old. Fever was seen in all cases. The fever was high grade, continuous in 60% and intermittent in 40% cases. General malaise and weakness were seen in all cases. Tongue coating was noticed in all cases. Splenomegaly was seen in 82.4% cases and hepatomegaly was seen in 58.4% cases. The widal agglutination by slide method showed rising titers in 49 cases. The tube agglutination was positive in 26 cases. Cases which showed positive results with both slide agglutination test and tube agglutination were 10. Blood culture was positive in 5 cases. The initial treatment started was amoxycillin in 27 cases. Amoxycillin was changed to cipro floxacillin in 11 cases and it was changed to ceftriaxone in 6 cases and amoxycillin was changed to chloramphenicol in 2 cases. Conclusion:Finally concluded that, this study on enteric fever shows the changing trends in the clinical features and management. Ceftriaxone and Cipro floxacillin were found to be very effective.