A Study on Breath Acetone in Diabetic Patients Using a Cavity Ringdown Breath Analyzer: Exploring Correlations of Breath Acetone With Blood Glucose and Glycohemoglobin A1C

Wang, Chuji; Mbi, Armstrong; Shepherd, M.

doi:10.1109/jsen.2009.2035730

Cited by 199 publications

(154 citation statements)

References 39 publications

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“…To better understand the correlation between acetone and glucose levels during fasting periods, we examined simultaneously breath acetone and blood glucose in the diet/fasting group during the fasting day (Day 2). The data is summarized in Figure 6, which confirmed the published literature data [31,32], indicating an overall trend of acetone increase when glucose levels decreased. However, it is important to mention that glucose and acetone are biomarkers reflective of different energy source pathways.…”

Section: Evaluation Of Breath Ketone As Biomarker Of Lipid Oxidationsupporting

confidence: 87%

“…Since ketones have been studied as a marker for blood glucose [31,32], breath acetone and blood glucose on the fasting day (Day 2) have been simultaneously measured for the diet-fasting group. Figure 6 shows the results, which can be fitted with an exponentially decaying curve with R 2 =0.52 (more details in discussion section).…”

Section: Evaluation Of Breath Ketone As Biomarker Of Lipid Oxidationmentioning

confidence: 99%

See 1 more Smart Citation

Breath Acetone as Biomarker for Lipid Oxidation and Early Ketone Detection

Prabhakar¹,

Quach²,

Wang³

et al. 2014

Glob J Obes Diabetes Metab Syndr

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Former ketone studies, including ketoacidosis (KAD), fasting ketosis (FK), nutritional ketosis (NK), and exercis-eaffected ketosis have brought great advances to the field of ketones. In the present work, blood, urine and breath ketone detections were evaluated systematically. We found that breath ketone (acetone) is the ketone of choice for detecting early stages of ketosis. In addition, acetone was correlated with respiratory quotient, and found to be a highly sensitive non-invasive biomarker of lipid oxidation. Furthermore, acetone was used for fast screening of ketosis or ketoacidosis in populations, and demonstrated value upon screening a population of 48 individuals, among which a type I diabetes case with early symptoms of KAD and FK case were identified.

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Section: Evaluation Of Breath Ketone As Biomarker Of Lipid Oxidationsupporting

confidence: 87%

Section: Evaluation Of Breath Ketone As Biomarker Of Lipid Oxidationmentioning

confidence: 99%

Breath Acetone as Biomarker for Lipid Oxidation and Early Ketone Detection

Prabhakar¹,

Quach²,

Wang³

et al. 2014

Glob J Obes Diabetes Metab Syndr

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“…Levels of isoprene have been reported at ~ 200 ppb [30,31], while those of acetone and methane can reach tens of ppm, depending upon the condition of the subject [31][32][33][34][35]. To simulate the relative concentrations possible in breath of isoprene and acetone, a mixture was made of 0.5 % of isoprene and 5 % acetone, buffered in air.…”

Section: Resultsmentioning

confidence: 99%

Trace species detection in the near infrared using Fourier transform broadband cavity enhanced absorption spectroscopy: initial studies on potential breath analytes

Denzer

Hancock

Islam

et al. 2011

Analyst

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Cavity enhanced absorption measurements have been made of several species that absorb light between 1.5 and 1.7 mm using both a supercontinuum source and superluminescent light emitting diodes. A system based upon an optical enhancement cavity of relatively high finesse, consisting of mirrors of reflectivity $99.98%, and a Fourier transform spectrometer, is demonstrated. Spectra are recorded of isoprene, butadiene, acetone and methane, highlighting problems with spectral interference and unambiguous concentration determinations. Initial results are presented of acetone within a breath-like matrix indicating ppm precision at <$10 ppm acetone levels. Instrument sensitivities are sufficiently enhanced to enable the detection of atmospheric levels of methane. Higher detection sensitivities are achieved using the supercontinuum source, with a minimum detectable absorption coefficient of $4 Â 10 À9 cm À1 reported within a 4 min acquisition time. Finally, two superluminescent light emitting diodes are coupled together to increase the wavelength coverage, and measurements are made simultaneously on acetylene, CO 2 , and butadiene. The absorption cross-sections for acetone and isoprene have been measured with an instrumental resolution of 4 cm À1 and are found to be 1.3 AE 0.1 Â 10 À21 cm 2 at a wavelength of 1671.9 nm and 3.6 AE 0.2 Â 10 À21 cm 2 at 1624.7 nm, respectively.

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“…In this work, a background subtraction method was used to determine the acetone concentration in breath samples, which was described in detail in our previous works [3,15]. In brief, the absorbance of the laboratory atmospheric air A atm is used as the background baseline, and subtracted from the breath gas absorbance A breath to calculate the absolute breath acetone concentration (the upper limit) n, which can be obtain by ( )…”

Section: Acetone Concentration Measuring Methodsmentioning

confidence: 99%

“…Tassopoulos et al found that breath acetone increased monotonically with elevated BG when 103 insulin-treated diabetic patients were grouped by their BG concentrations [2]. Likewise, a linear correlation between the mean group breath acetone concentration and the mean group BG concentration was observed in a study of 30 T1D subjects when they were grouped by different BG concentrations [3]. More recently, a weak positive relationship was found between BG and breath acetone in 113 children and adolescents with T1D [4].…”

Section: Introductionmentioning

confidence: 99%

Study of Breath Acetone in a Rat Mode of 126 Rats with Type 1 Diabetes

Wang¹,

Sun²,

Zhao³

et al. 2017

J Anal Bioanal Tech

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We investigate correlations of breath acetone with blood glucose (BG) and blood beta-hydroxybutyrate (BHB) in a rat model of 126 streptozotocin-induced Type 1 diabetic (T1D) and 32 healthy rats, and evaluate the role of breath acetone analysis as a non-invasive alternative in diabetes screening and management. We conducted breath acetone analysis using a T1D rat model under various conditions, including fasting and insulin-treated. Breath acetone concentrations were measured using a cavity ringdown breath acetone analyzer, LaserBreath-001. The results showed that the breath acetone, BG, and BHB in the T1D rat group were significantly different from those in the healthy group (P<0.05). Significant positive relationships between breath acetone and blood BHB existed in both T1D and healthy groups, as well as in a group of T1D rats under fasting condition and insulin treatment. When the BG concentrations were grouped as follows: 16.5-24.4, 24.5-27.7, and 27.8-41.7 mmol/L, a moderate negative correlation between breath acetone and BG was observed in the T1D group. Furthermore, the accuracy of diabetes screening using breath acetone was analyzed using the receiver operating characteristic (ROC) analysis method and results showed that the accuracy is low when the area under ROC curve (AUC) is <0.6425.

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A Study on Breath Acetone in Diabetic Patients Using a Cavity Ringdown Breath Analyzer: Exploring Correlations of Breath Acetone With Blood Glucose and Glycohemoglobin A1C

Cited by 199 publications

References 39 publications

Breath Acetone as Biomarker for Lipid Oxidation and Early Ketone Detection

Breath Acetone as Biomarker for Lipid Oxidation and Early Ketone Detection

Trace species detection in the near infrared using Fourier transform broadband cavity enhanced absorption spectroscopy: initial studies on potential breath analytes

Study of Breath Acetone in a Rat Mode of 126 Rats with Type 1 Diabetes

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