A Study on Association of Serum Osteocalcin and Adiponectin with Diabetic Markers in Genetically High Risk for Type 2 Diabetes Population

Abstract

Aims: In view of significant role of osteocalcin and adiponectin in the onset of insulin resistance and diabetes in rat model and cell line studies we aimed to study the influence of family history for diabetes on osteocalcin and adiponectin levels and their role in initiating the changes in diabetic markers in healthy adult springs of diabetic parents, thus a hypothesis can be drawn on their role in developing diabetes in high risk population. Methodology: Age between 18 to 22 years was selected and divided into three groups. Group I: control group consists (n=81) with no family history of diabetes. Group II: (n=147) with one of their parents with history of type 2 diabetes. Group III: (n=47) with both parents having history of type 2 diabetes. In all the groups we estimated fasting plasma glucose, lipid profile, insulin and adiponectin and osteocalcin. Results: We observed significant lower levels of adiponectin 8.7 ± 1µg/ml in group-III

Correlation of Serum Adiponectin, Fasting Serum Glucose and Serum Insulin in Samples Received in a Tertiary Care Hospital in Central India

“…Sull et al 10 also concluded his study that family history of diabetes is associated with hypoadiponectinemia. Recently, K. Bose et al 11 also found in his study the significant difference in serum adiponectin between offsprings of both diabetic parents and offspring of single diabetic parent. (P=0.000**).…”