A Study on Antibiotic Sensitivity Pattern in Children Hospitalized for Urinary Tract Infection in a Tertiary Care Hospital in South India

Abstract

Background:The etiology of urinary tract infection (UTI) and their antibiotic sensitivity pattern vary from time to time and across different areas in India. This study is designed to analyse the resistance of uropathogens to commonly used antibiotics. Aim: To study antibiotic resistance trends of uropathogens and assess the antimicrobial utilization pattern according to the antimicrobial susceptibility test in the paediatric department of a tertiary care hospital. Materials and Methods: It was an ambispective observational cohort study conducted in 144 patients admitted with UTI for a period of one year and observed for recurrent UTI for the next one year.Results: E. coli (50%) was found to be the most common cause of UTI followed by Klebsiella (22.22%). E. coli and other isolates were more sensitive to Meropenem and Amikacin compared to other antibiotics tested. These isolates show increasing resistance to commonly used antibiotics. Most (74.31%) children were given single antimicrobial agent. Majority of the children were prescribed with Cephalosporins (60.41%), followed by Penicillin derivatives (29.17%) and Carbapenems (11.11%). Out of 144 children, antibiotics were prescribed according to culture sensitivity report in only 31.94%. Among children whose antibiotics were not selected based on the culture report, 40 had recurrent UTI in the following year. Conclusion: Recurrent UTI can occur if adequate antimicrobial therapy based on antimicrobial susceptibility test is not administered during the initial UTI episode. Close cooperation between physicians, microbiologists and pharmacists is essential to ensure that UTI patients receive antimicrobial therapy, if required based on local susceptibility data.

Occurrence of antibiotic resistant bacteria causing UTIs among children under school age in Soran city, North of Iraq

“…3m). In our study and after we mentioned all previous susceptibility tests results to 14 different antibiotics which commonly used in hospitals, shown us that a higher prevalence rate of resistance to commonly prescribed antibiotic agent, all the bacterial uropathogens showed [49] in India, by AbdulRazzaq (2013) [18] in Mosul, and by Mezal and coworkers (2011) [50] in Basrah. while this drugs exhibited low resistant rate in another study outside Iraq such as Jha and Bapat [51] reported that all the organisms causing UTI were sensitive to ciprofloxacin.…”