A study on alpha-fetoprotein and endodermal sinus tumor

Alpha-fetoprotein levels correlate with the pathologic grade and surgical outcomes of pediatric retroperitoneal teratomas

“…5). This observation is particularly important because of the existing controversy regarding the utility of AFP levels prior to 2 months of age [22], and a prior study found that AFP was predictive, but not definitive, in differentiating immature from mature teratomas [21]. Furthermore, since AFP levels correlate with the grade of immature RT in our study, and higher grade is associated with increased surgical morbidity, we propose that serum AFP may serve to predict peri-operative risks in the pediatric population.…”

“…While in this series none of the patients relapsed, there is still some concern regarding the ultimate pathology. Although none of our patients relapsed, it should be noted that alpha-fetoprotein has been associated with tumors containing endodermal sinus elements, and in these cases has been cited as an indicator of tumor recurrence [22].…”

Experimental yolk‐sac tumors produced by fetectomy without virus infection in rats

“…The incised uterus was not closed, and the abdominal wall was sutured. that contain yolk-sac tumor elements, and not in pure seminomas and teratomas that consist solely of well-differentiated tissues (Itoh et al, 1974;Tsuchida et al, 1975). Therefore, the determination of serum AFP levels can be used for detection of yolk-sac tumors.…”

Maternal Serum Alpha-Fetoprotein and Epithelial Tumour Marker Concentrations Are Not Increased by Fetal Sacrococcygeal Teratoma

“…Very few cases, however, are diagnosed in the first or early second trimester of pregnancy (Kuhlman et al, 1987;Holzgreve et al, 1987). Similarly, scanty information is available as regards the use of biochemical markers as prenatal diagnostic aids, though several authors have suggested that circulating alpha-fetoprotein (AFP) concentrations, particularly their changes, can be used postnatally to differentiate benign from malignant tumours Addressee for correspondence: P. Kirkinen (Grosfeld et al, 1976;Gonzales-Crussi et al, 1978;Tsuchilda et al, 1975;Bilik et al: 1993).…”