A study on adverse drug reactions in a tertiary care hospital of Northeast India

Lihite, Ratan J.; Lahkar, Mangala; Das, Sukirti; Hazarika, Dibya Jyoti; Murali, Kotni; Maqbool, Mudasir; Phukan, Swapna

doi:10.1016/j.ajme.2016.05.007

Cited by 37 publications

(32 citation statements)

References 8 publications

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“…This was in accordance with the study conducted by Shamna M et al (2013) where it was 53.06% in males and 46.93% in females but in contrast the study conducted by Lihite RJ et al (2017) has shown that prevalence of ADRs was higher in females 53.8% than males 46.1%. 3,9 In the present study prevalence of ADRs was higher in the age group of 51-60 years (26.32%), whereas the study conducted by Lihite RJ et al (2017) has shown highest prevalence of 37.4% in the age group of 21-30 years. 9 The study conducted by Shamna M et al (2013) has shown highest prevalence of 44.89% in geriatric patients.…”

Section: Discussionsupporting

confidence: 92%

“…3,9 In the present study prevalence of ADRs was higher in the age group of 51-60 years (26.32%), whereas the study conducted by Lihite RJ et al (2017) has shown highest prevalence of 37.4% in the age group of 21-30 years. 9 The study conducted by Shamna M et al (2013) has shown highest prevalence of 44.89% in geriatric patients. 3 In the current study the most common ADRs observed were related to gastrointestinal tract 35.09%.…”

Section: Discussioncontrasting

confidence: 57%

“…(2017) most ADRs were observed related to skin 63.52%. 9 In present study most common drugs causing ADRs were NSAIDs 29.82%. In contrast the study conducted by Gor AP et al (2008) has shown penicillin related drugs as most common drug causing ADRs 22.22%.…”

Section: Discussionmentioning

confidence: 49%

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Prevalence of Drug Interactions and Adverse Drug Reactions in a Tertiary Care Hospital

Konduru¹,

Pratyusha²,

Yogitha³

2019

Int. Res. J. Pharm.

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In healthcare delivery system, medicines play a key role in reducing patient's suffering. Nonetheless, irrational use of medicines remains a major issue facing most health systems across the world. This might eventually lead to drug interactions and adverse drug reactions (ADRs). Hence a study was planned with an aim to evaluate the prevalence of drug interactions and adverse drug reactions in a tertiary care hospital. A total of 500 patients were selected by convenience sampling method. Complete case records of all the 500 subjects were collected. 26.32% (n = 15) ADRs are seen in the age group of 51-60 years. 70.18% (n = 40) of ADRs are seen in males. Irrational prescribing is seen in 30.2%. Most of the (Potential Drug Drug Interactions) PDDIs are due to the combined use of aspirin and clopidogrel (n = 76). Hence, by evidence based practice and rational drug use guidelines, the adverse drug effects can be minimized. Also, by minimizing polypharmacy the number of ADRs can be reduced, thereby decreasing the cost of health care.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 57%

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Prevalence of Drug Interactions and Adverse Drug Reactions in a Tertiary Care Hospital

Konduru¹,

Pratyusha²,

Yogitha³

2019

Int. Res. J. Pharm.

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“…Headaches were observed in 26.2% of the patients and insomnia in 21.4%. GIT was the most affected site in studies by Kumar 22,34,35 Total 50% of the cases were classified as probable when causality assessment was done while 38.1% were classified as possible. None of the ADRs were unlikely, conditional or assessable according to the causality assessment.…”

Section: Discussionmentioning

confidence: 99%

Patterns of adverse drug reactions: a study in a tertiary care

Kumar

2019

Int J Basic Clin Pharmacol

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Background: Adverse drug reaction, usually reported by pharmacovigilance, either through health care professionals or the patients themselves is of utmost importance to give an accurate estimate of the severity of the drug and also if the ADRs are casual, preventable or severe.Methods: A total of 42 patients satisfied the WHO definition of ‘adverse drug reactions’ were included in the study. The demographic details were taken, and the regular physical examination and clinical examination was done for all the patients. The latest drug they were on and the dosage were analyzed and the type of reaction was assessed. The causality, severity and preventability were also assessed.Results: Majority of the ADRs were found in the medicine department, followed pulmonology, obstetrics-gynecology and paediatrics. B-lactams were the major cause of ADRs with 42.2%, followed by NSAIDs with 23.8%, fluoroquinolones with 19% and 9.5% due to antitubercular drugs. 66.7% of the ADRs were mild, 28.6% were moderate and 4.8% were severe. The most common type of ADR were skin rashes (40.5%), urticara (16.7%), headaches (26.2%), insomnia (21.4%), diarrhoea (21.4%), abdominal pain (14.3%) and vomiting (4.8%). Most of the ADRs were evaluated as probably preventable (69%), definitely preventable (26.2%), non preventable (4.8%).Conclusions: Most of the drug reactions are mild and preventable. More health care professionals as well as patients need to be aware of the drug reactions at much early age so as to prevent the condition before it becomes serious.

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“…Adverse drug reaction simplify that any causal relationship between the drug and the event is suspected/this implies that there is a suspected relatedness to the administered drug. Off-label use, OTC drug use (India ranks 11th position in the global for OTC drug use), drug misuse, drug overuse, medication error includes prescribing error, dispensing error, administration error and drug abuse are also tend to cause adverse drug reaction [2].…”

Section: Introductionmentioning

confidence: 99%

Recent Development of Pharmacovigilance System in India

Hb¹

2018

J Pharma Care Health Sys

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Recently India has developing in many aspects such as monitoring and reporting of adverse drug reaction. Pharmacovigilance programme introduced in India for better pharmaceutical care to improve patient safety. Creating awareness is crucial to enhance for better clinical practice. Numerous of the adverse drug reactions were reported like Metformin, Olanzapine etc. Healthcare professionals, other healthcare professionals and nonhealthcare professionals are attentively participating in monitoring and reporting of ADRs via enhancing rational use of medications and genuine treatment pattern. These consequences decrease the failure of treatment and progress in the medication adherence.

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A study on adverse drug reactions in a tertiary care hospital of Northeast India

Cited by 37 publications

References 8 publications

Prevalence of Drug Interactions and Adverse Drug Reactions in a Tertiary Care Hospital

Prevalence of Drug Interactions and Adverse Drug Reactions in a Tertiary Care Hospital

Patterns of adverse drug reactions: a study in a tertiary care

Recent Development of Pharmacovigilance System in India

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