A field experiment was conducted during the rabi season of 2021-22 at Research Farm A, College of Agriculture, Ganj Basoda, District Vidisha (M.P.) to evaluate the bio-efficacy of tank-mix herbicides in wheat. The experiment consisting of nine treatments was laid out in randomized block design with three replications. The results revealed that tank-mix application of clodinafop propargyl + metsulfuron methyl @ 60 + 4 g a.i. ha -1 reduced significantly the weed density (14.61 No./m 2 ), dry weight (24.73 g/m 2 ) and weed index (3.25%) while highest weed control efficiency (85.26%), herbicide efficiency index (3.587), weed persistence index (1.229), crop resistance index (9.368), grain yield (4854 kg ha -1 ) and crop dry matter yield (12643 kg ha -1 ) to over all the herbicidal treatments but found at par with clodinafop propargyl + metribuzin @ 60 + 175 and clodinafop propargyl + carfentrazone ethyl @ 60 + 20 g a.i. ha -1 .