A Study of Vitamin D Level in Newborn with Special Reference to Correlation with Gestational Age, Morbidity and Maternal Vitamin D Level

Abstract

Background: Recently the high prevalence of vitamin D level deficiency in general population. Pregnancy and preterm deliveries are known as risk Factors for vitamin d deficiency.. In the study we aimed to compare vitamin D level in term and preterm newborn mother pair. Methods: We prospectively collected vitamin D blood level in term and preterm newborn with their mother's vitamin D level in neonatal ICU at tertiary health care centre. Results: Total 80 newborn mother pair was recruited in study, including 44 preterm (55%) and 36 term (45%) newborns In total 41.9% and 55.9% of preterm and term newborn had vitamin D deficiency, respectively and 47.6% & 32.5% of preterm and term newborn had vitamin D insufficiency, respectively. Among all newborns, 48.9% had vitamin D deficiency, although the difference between term and preterm newborn was not statistically significant. Based on findings, serum vitamin D levels in mother and newborns were significantly correlated (p<0.001). The Data suggest that preterm & term newborn with vitamin D deficiency have higher incidence of ROP & sepsis respectively as compared to others (p<0.001). Conclusion: According to present study, vitamin D level in mother and newborn were significantly correlated and vitamin D level deficiency in preterm and term newborn is associated with higher chances of development of ROP and early onset septicemia respectively, there is no significant correlation between gestational age and vitamin D level in newborn mother pair.