A study of viral pathogens in bat species in the Iberian Peninsula: identification of new coronavirus genetic variants

Moraga‐Fernández, Alberto; Sánchez‐Sánchez, Marta; Queirós, João; Lopes, Ana M.; Vicente, Joaquín; Pardávila, Xosé; Sereno-Cadierno, Jorge; Alves, Paulo C.; Fuente, José de la; Mera, Isabel G. Fernández de

doi:10.1080/23144599.2022.2139985

Cited by 7 publications

(5 citation statements)

References 63 publications

(84 reference statements)

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“…The availability of a highly sensitive and specific diagnostic assay is indispensable for the identification of cases, efficient contact tracing, and the diagnosis of suspected SARS-CoV-2 infections. Our findings indicate that in respiratory samples, shedding endured for approximately 18-20 days, with the highest shedding levels occurring in the respiratory specimens of positive cases around 10 to 14 days after the onset of symptoms [29][30][31][32][33][34][35]. These insights have significant implications for public health strategies aimed at curbing the spread of the virus.…”

Section: Discussionmentioning

confidence: 73%

Genetic Analysis and Epidemiological Impact of SARS-CoV-2: A Multinational Study of 1000 Samples Using RT-PCR

Banser,

Abduljaleel,

Alzabeedi

et al. 2024

Applied Microbiology

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The ongoing global public health challenge posed by the COVID-19 pandemic necessitates continuous research and surveillance efforts. In this study, we comprehensively analyzed over 1000 COVID-19 RT-PCR tests conducted on a cohort of 1200 patients in Saudi Arabia. Our primary goal was to investigate mutations in specific genes RdRp, N, and E different infection and recovery stages in Saudi patients with SARS-CoV-2. We also extended our analysis to include patients of various nationalities residing in Saudi Arabia, with the overarching objective of assessing these genes as markers for COVID-19 presence and progression. To diagnose and investigate potential genetic variations in COVID-19, we engaged RT-PCR. Our study primarily focused on detecting mutations in the RdRp, N, and E genes in Saudi patients with SARS-CoV-2, as well as individuals from various national residing in Saudi Arabia. This molecular technique provided valuable insights into the virus’s genetic makeup during infection and recovery. In our analysis of 671 positive COVID-19 cases, diverse gene involvement patterns were observed. Specifically, 55.91% had mutations in all three genes (RdRp, N, and E), 62.33% in both N and E genes, and 67.16% in RdRp and N genes. Additionally, 30.75% exhibited mutations exclusively in the RdRp gene, and 51.58% had mutations in the N gene. The N gene, in particular, showed high sensitivity as a marker for identifying active viral circulation. Regarding the temporal dynamics of the disease, the median duration between a positive and a subsequent negative COVID-19 RT-PCR test result was approximately 33.86 days for 44% of cases, 14.31 days for 30%, and 22.67 days for 4%. The insights from this study hold significant implications for managing COVID-19 patients during the ongoing pandemic. The N gene shows promise as a marker for detecting active viral circulation, potentially improving patient care and containment strategies. Establishing a defined positive threshold for diagnostic methods and correlating it with a low risk of infection remains a challenge. Further research is needed to address these complexities and enhance our understanding of COVID-19 epidemiology and diagnostics.

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Section: Discussionmentioning

confidence: 73%

Genetic Analysis and Epidemiological Impact of SARS-CoV-2: A Multinational Study of 1000 Samples Using RT-PCR

Banser,

Abduljaleel,

Alzabeedi

et al. 2024

Applied Microbiology

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“…All of the species involved in study, excluding M. mystacinus , have been prevoiusly identified as hosts for various coronaviruses. [ 21 , 22 ]…”

Section: Resultsmentioning

confidence: 99%

Hibernating vesper bats are a weak source for biomonitoring of coronaviruses

Goll,

Dutra,

Nowicka

et al. 2024

One Health

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“…SARS-CoV-2 causes a wide range of wild and farm animals, humans as well as birds. An experimental study revealed a antiviral activity of Ivermectin against CoV virus.Genomic variants of this virus may cause future epidemic or pandemic due to the rapid evolution of corona viruses [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Seasonal distribution and upsurge of respiratory viruses among indigenous tribes with ILI and SARI in a far-flung Car Nicobar Island

Muruganandam,

Vipat,

Jadhav

et al. 2024

BMC Infect Dis

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Background Respiratory viral illnesses among children are a prominent cause of morbidity and mortality in the developing world. The aim of this study is to understand the seasonal pattern and surge of respiratory viruses among the Nicobarese tribe. Methods Respiratory specimens were collected from both ARI and SARI cases attended the BJR district hospital in Car Nicobar Island, India, between 2021 and 2022. Respiratory viruses were identified from the specimens by using the qRT-PCR assay. Meteorological parameters were collected and evaluated using Microsoft Excel and SPSS 21. The significant association between the surge of respiratory viruses and each climatic parameter was evaluated. Results In this hospital-based cross-sectional study, 471 ILI cases were enrolled, and 209 of these were positive for respiratory viral infections. Of these respiratory virus infections, 201 (96.2%) were infected with a single respiratory virus infection, and 8 (3.8%) had mixed viral infections. Fever, cough, and chills were the most common symptoms of respiratory illness among this indigenous population. There was a significant link between respiratory viruses and influenza-like illness in children (below 5 years and 6 to 15 years). Conclusion This prevalence study revealed that viral respiratory infections were more common in children than adults. Among these respiratory viruses, respiratory syncytial virus A (RSV) and influenza B virus were predominantly reported among tribal children up to age five years. In the year 2021, these viruses were recorded frequently during the winter season. Climate factors such as high humidity, high precipitation, moderate temperature, and moderate rainfall are found to be correlated with respiratory viral infections. This study implicates important information for preventing a further outbreak of respiratory viral infections in Car Nicobar Island.

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A study of viral pathogens in bat species in the Iberian Peninsula: identification of new coronavirus genetic variants

Cited by 7 publications

References 63 publications

Genetic Analysis and Epidemiological Impact of SARS-CoV-2: A Multinational Study of 1000 Samples Using RT-PCR

Genetic Analysis and Epidemiological Impact of SARS-CoV-2: A Multinational Study of 1000 Samples Using RT-PCR

Hibernating vesper bats are a weak source for biomonitoring of coronaviruses

Seasonal distribution and upsurge of respiratory viruses among indigenous tribes with ILI and SARI in a far-flung Car Nicobar Island

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