A Study of Vesicorenal Reflexes and of the Possibility of a Renorenal Reflex

Responses of Renal Function to Elevated Intravesical Pressure

“…It is established that bladder distension in both man and experimental animal is associated with a reduction in urine flow (Farrel, 1931;Prat, 1956;Tolls and Dille, 1957;Langley and Kimura, 1959;Soloway et al, 1972;Helin et al, 1975). Two theories have been proposed to explain the phenomenon.…”

“…The influence of the elevated intravesical pressure on renal function when there is no back pressure and the urine flows freely is still controversial. Several investigators, most of them using animal models, have demonstrated an inverse relationship between bladder pressure and urine output (Lucas, 1908;Pflaumer, 1919;Farrel, 1931 ;Miller and Lampton, 1941 ;Lawsonand Tomlinson, 1951;Krzeski and Trzebski, 1956;Prat, 1956;Myint and Murphy, 1957;Tolls and Dille, 1957;Langley and Kimura, 1959;Boyarsky and Martinez, 1962;Shin and Hong, 1962;Lytton ef al., 1967). This phenomenon has been attributed to a neurogenic reflex activated by the elevated intravesical pressure (Boeminghaus, 1929).…”

Effect of Urinary Bladder Distension on Renal Blood Flow, Blood Pressure and Plasma Renin Activity

“…Prat (1956) reported that renal plasma flow measured by p-aminohippuric acid clearance decreased in 6 out of 11 subjects during bladder distension. Farrell (1931) observed an increase in renal volume measured by an oncometer during bladder distension, while Mukherjee The pressor response during bladder distension has been considered to be mediated through a spinal reflex arc. The afferent pathways of the reflex arc have been thought to be carried mainly by the pelvic nerve and partially by the hypogastric nerve (Lapides and Lovegrove 1965; Taylor 1968).…”

Effect of a Full Bladder on Urine Production in Humans

“…These tension receptors are most likely situated in the trigone of the bladder, but faster adapting receptors located outside the walls of the bladder have been described (25). Most animal models have found the afferent pathway of the vesico-renal reflex mediated via the pelvic nerves, but also the hypogastric nerves seem to be involved (4,6,7). The efferent pathway may be via either the splanchnic or the renal sympathetic nerves.…”

“…Previous studies in humans and animals have demonstrated an inverse relationship between urine production and distension of the urinary bladder (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). Several theories have been proposed to explain this phenomenon.…”