A study of various factors associated with sexual dysfunction in males with type 2 diabetes mellitus

Abstract

Background: SD is very common in type 2 diabetic men. Many middle aged and older adults with diabetes are sexually active, but the rate of sexual inactivity is higher than in non-diabetic subjects. The objective of this study was to study various factors associated with sexual dysfunction in males with type- 2 diabetes mellitus.Methods: A total of 60 male type 2 diabetic subjects were studied. They were divided in to two groups, 42 subjects with SD were in one group and 18 subjects with normal sexual function were in the second group. Differences between groups were assessed for statistical significance using T-test, Mann-Whitney test and Chi-square test, where ever applicable. The data were presented as Mean±Standard deviation or percentages.Results: The prevalence of SD was 70%, ED was 93%, Orgasmic dysfunction was 38 %, 9 had HSDD (21%) and 22 had premature ejaculation (52%). The age (p = 0.335), duration of DM (p = 0.097), BMI (p = 0.717), WC (p = 0.138) were not significantly different between two groups. FPG (p = 0.000), PPG (p = 0.000) and HbA1c (p = 0.000) were significantly higher in SD group. Non-HDL cholesterol level (p = 0.001) and TG level (p = 0.021) were significantly higher in SD group. The eGFR (p = 0.150) was not significantly different between two groups. Spot urine protein creatinine ratio (p = 0.002) was significantly higher in SD group.Conclusions: It was concluded that SD is a highly prevalent problem in males with type 2 DM. ED is the most common form of SD, followed by PE, Orgasmic dysfunction and HSDD. The age, duration of DM, BMI and WC are not associated factors of SD.

Assessment of erectile dysfunction and other sexual dysfunction in men with type 2 diabetes mellitus: A multicenter observational study in North India

“…A consistent risk factor for ED includes increasing age, in both the diabetic and general population. 12 In the present study, a significant association was observed between age and prevalence of ED; the proportion of ED in diabetic patients increased with age, and the highest J o u r n a l P r e -p r o o f prevalence was observed in the >60-year age category (48.1%) and the lowest in the ≤30-year age category (0.00%). In another Indian study, the prevalence of ED was found to be 10.3% and 54.6% in <40-year and 40-59-year age-groups of patients, respectively.…”

“…Similar to the results of our study, Jakka and Ramesh had reported orgasmic dysfunction in about 38% of their study population, comprising males with T2DM. 12 Further, the study by Malavige et al reported premature ejaculation in 40% of patients with diabetes. They also reported a strong association between ED and premature ejaculation (odds ratio = 4.41; 95% confidence interval = 2.08-9.39) in patients with T2DM.…”

“…11 The prevalence of ejaculatory disturbance in diabetic males is estimated to be around 9%-31%, while that of orgasmic dysfunction is around 7%-8%. 12 The main concern with orgasmic dysfunction in young males is the failure to inseminate, thereby leading to male infertility. 11 Peripheral neurological interruptions as seen in diabetic neuropathy are one of the causes of OFD.…”

“…Further poor glycemic controls are strongly associated with premature ejaculations in males with T2DM; however, the role of glycemic control in orgasmic dysfunction is not clearly understood. 12 Endothelial dysfunction plays a key role in DM-associated ED. Alterations in the functionality of the penile endothelium, a specialized component of the vascular system, lead to complications such as ED.…”