A Study of Variation in Adult Thrombocytopenic Histograms A Graph Often Overlooked

Abstract

Background: With the advent of automation in hematology, both platelet indices and their histograms are available from the blood cell counters at no extra cost or time. The variations of histograms in various mechanisms of thrombocytopenias are explored in this study.Methods: Adults with thrombocytopenia determined with (name of the analyser)were categorized into four groups based on the mechanism of thrombocytopenia and variations in platelet histograms were studied in all groups. Data was collated and analysed using Microsoft Excel.Results: A total of 224 adults with thrombocytopenia were seen, most of them had hyperdestructive type (73.6%) followed by hypoproductive type (16.08%), abnormal pooling (6.3%) and EDTA induced thrombocytopenia (4.01%). The following variations in histogram were seen; Normal curve(8.03%), Curve not touching/reaching the baseline (43.75%), Broad based curve (10.71%), Bimodal curve (7.14%), Curve with short peak (25.9%) and Saw-tooth appearance of curve (4.47%) and correlated with the above mentioned mechanisms of thrombocytopenias using SPSS software version 20. Conclusion:An awareness regarding the variations in the platelet curve ensures a good correlation with its numerical parameters and also with the etiology of thrombocytopenias. With the era of automation taking over in most of the laboratories, it is imperative to have knowledge about these simple yet, often overlooked platelet histograms

Spectrum of Platelet Histograms in Adult Thrombocytopenia

“…Hyperdestructive cases of thrombocytopenia included fever of varying etiology, liver disease, ITP, Sepsis and renal diseases 13 . In our study distribution of aetiologies were similar to other studies by Katti et al and Shetty et al 12,14 . Dengue cases, followed by malaria predominated during the study.…”

“…The analyser display platelet histograms along with other platelet indices were also available 11 . The thrombocytopenia cases in our study fell into third decade of life with male to female ratio being 2.2:1, similar to study conducted by Shetty et al 12 . Hyperdestructive cases of thrombocytopenia included fever of varying etiology, liver disease, ITP, Sepsis and renal diseases 13 .…”

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