A study of treatment outcomes of pulmonary tuberculosis and extrapulmonary tuberculosis patients in a tertiary care centre

Abstract

Background: Directly observed treatment remains one of the most widely-accepted global health interventions for tuberculosis. Tuberculosis treatment outcome is one of the performance indicators of the programme set by World Health Organization.Methods: This study was conducted in a tertiary care centre Chennai. A retrospective analysis of the profile and treatment outcome of all tuberculosis patients registered from January 2015 to December 2015 at DOTS centre under RNTCP was conducted. Data on treatment outcomes was analysed using appropriate statistical methods and percentages were calculated.Results: Out of 118 TB cases, 59.3% had pulmonary while 40.7% had extra-pulmonary TB. Sputum positive PTB is more common than sputum negative which is 74.2% and 25.8% respectively. Frequency of TB lymphadenitis is being the common presentation among extra pulmonary TB cases, followed by TB pleurisy. Success rate (cure rate plus treatment completion rate) for new cases was 63.1% and for retreatment cases was 36.9% while the overall success rate was 81%.Conclusions: Effective measures have to be taken in the programme to move forward to help in the eradication of TB. Tuberculosis mostly affects males of the economically productive age group and causes economic losses. The success rate of new cases was higher compared to retreatment cases though the overall success rate was lower compared to the RNTCP norms. Proper education on DOTS can help in improving the success rate and cure rate.

Treatment outcomes of patients with tuberculosis in war affected region of Khyber Pakhtunkhwa, Pakistan

“…We found that the overall TB treatment success (i.e. having an outcome of cured or treatment completed) at the end of the treatment was 86.2%, which is similar to other resource-constrained countries such as India (81-83%) [23][24][25], Ethiopia (85.6%) [26], Nigeria (83.1%) [27], Uzbekistan (83%) [28], Thailand (78.5-87.5%) [29], and higher than war affected countries such as Somalia (81.8%) [30], Iran (83.1%) [31] and Afghanistan (77.7%) [32]. However, the treatment success rate in our study was lower than the treatment success rate reported in the previous studies in Pakistan [13,33].…”

Treatment outcomes of patients with tuberculosis in war affected region of Khyber Pakhtunkhwa, Pakistan

“…In this study, the overall TB treatment success rate is higher from previous published studies in different countries; studies from India reported the overall treatment success rates were (81%) [23], (83%) [24], (84.21%) [25], and (86%) [26], in Thailand the success rate was (78.5%) for patients in the TB Case Management cohort, while the success rate is high (87.5%) for patients in the National Health Security Office cohort [27], Iran (83.1%) [28], Uzbekistan (83%) [29], Denmark (80.5%) [30], Malaysia (67.26%) [31], Ethiopia (85.6%) [32], Somalia (81.8%) [33], Nigeria (83.1%) [34], in…”

Treatment outcomes of patients with tuberculosis in war affected region of Khyber Paktunkhwa, Pakistan

“…In this study, the overall TB treatment success rate is higher from previous published studies in different countries; studies from India reported the overall treatment success rates were (81%) [17], (83%) [18], (84.21%) [19], and (86%) [20], in Thailand the success rate was (78.5%) for patients in the TB Case Management cohort, while the success rate is high (87.5%) for patients in the National Health Security Office cohort [21], Iran (83.1%) [22], Uzbekistan (83%) [23], Denmark (80.5%) [24], Malaysia (67.26%) [25], Ethiopia (85.6%) [26], Somalia (81.8%) [27], Nigeria (83.1%) [28], in…”