A Study of the Vibration of the Basilar Membrane in Human Temporal Bone Preparations by the Use of the Mossbauer Effect

Gundersen, Terje; Skarstein, øyvin; Sikkeland, Torbjarn

doi:10.3109/00016487809124740

Cited by 58 publications

(43 citation statements)

References 7 publications

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“…The passive model showed good matching with Greenwood function, which means that it can replicate frequency to place characteristic of the cochlea. The active model results presented BM velocity with respect to input stapes velocity for passive cochlea and it was in good agreement with measurement by Gundersen et al (1978) and Stenfelt et al (2003).…”

Section: Discussionsupporting

confidence: 71%

A summary of results in modeling plaque formation and development, cochlea mechanics and vestibular disorders

Filipović¹,

Radović²,

Isailović³

et al. 2016

J Serb Soc Comp Mech

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In this review we present scientific results from three EC FP7 projects: ARTREAT, SIFEM and EMBALANCE. The title of FP7 ARTREAT project was: Multi-level patient-specific artery and atherogenesis model for outcome prediction, decision support treatment, and virtual hand-on training. Researchers from the University of Kragujevac and BioIRC participated in this project. The original method for plaque formation and development was developed and validated on the pilot study patients for coronary and carotid arteries in EU clinical centers. Another FP7 project was SIFEM with the title: Semantic Infostructure interlinking an open source Finite Element tool and libraries with a model repository for the multi-scale Modelling and 3d visualization of the inner-ear. Мethodology for cochlea model with tapered and rectangular basilar membrane with passive and active model was developed.The main part of EMBALANCE FP7 project was modelling of vertigo diseases. Threedimensional biomechanical model of semi-circular canals was described with full 3D fluidstructure interaction of particles, wall, cupula deformation and endolymph fluid flow. The model is compared with clinical data and nystagmus measurement on the vertigo patients.

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Section: Discussionsupporting

confidence: 71%

A summary of results in modeling plaque formation and development, cochlea mechanics and vestibular disorders

Filipović¹,

Radović²,

Isailović³

et al. 2016

J Serb Soc Comp Mech

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“…more closely to the base of the cochlea for higher frequency sounds [von Békésy, 1953;Gundersen et al, 1978]. Also shown in human cadaveric specimens is that bone stimulation produces a maximum at a similar position on the basilar membrane as acoustic stimulation [Stenfelt et al, 2003].…”

mentioning

confidence: 87%

“…Also shown in human cadaveric specimens is that bone stimulation produces a maximum at a similar position on the basilar membrane as acoustic stimulation [Stenfelt et al, 2003]. Another fundamental property of the travelling wave [Wilson and Johnstone, 1975] is a place-dependent phase response, in which the phase increases from the base to the apex of the cochlea, also shown in human cadaveric specimens [von Békésy, 1953;Gundersen et al, 1978]. This place dependence results in a delay between sound entering the cochlea and the resultant physiological response that is inversely related to the stimulus frequency.…”

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confidence: 98%

Electrophysiological Evidence of the Basilar-Membrane Travelling Wave and Frequency Place Coding of Sound in Cochlear Implant Recipients

et al. 2017

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Aim: To obtain direct evidence for the cochlear travelling wave in humans by performing electrocochleography from within the cochlea in subjects implanted with an auditory prosthesis. Background: Sound induces a travelling wave that propagates along the basilar membrane, exhibiting cochleotopic tuning with a frequency-dependent phase delay. To date, evoked potentials and psychophysical experiments have supported the presence of the travelling wave in humans, but direct measurements have not been made. Methods: Electrical potentials in response to rarefaction and condensation acoustic tone bursts were recorded from multiple sites along the human cochlea, directly from a cochlear implant electrode during, and immediately after, its insertion. These recordings were made from individuals with residual hearing. Results: Electrocochleography was recorded from 11 intracochlear electrodes in 7 ears from 6 subjects, with detectable responses on all electrodes in 5 ears. Cochleotopic tuning and frequency-dependent phase delay of the cochlear microphonic were demonstrated. The response latencies were slightly shorter than those anticipated which we attribute to the subjects' hearing loss. Conclusions: Direct evidence for the travelling wave was observed. Electrocochleography from cochlear implant electrodes provides site-specific information on hair cell and neural function of the cochlea with potential diagnostic value.

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“…Another effect at low frequencies, however, is that the ratio between the BM width and the fluid chamber width, B/W, in the linearly tapered model becomes much larger than in the uniform model with averaged parameters, which leads to a decrease of the peak BM velocity. Figure 8 shows the BM frequency response calculated at about 12 mm from the base for the human cochlea in comparison with the BM response measured in a human cadaver by Gundersen et al (1978) and Stenfelt et al (2003). Results are plotted against a non-dimensional variable, f/BF(x 0 ) (Zweig, 1976;Shera, 2007), where f is the driving frequencies and BF(x 0 ) denotes the best frequency at which the BM motion is maximum for the level at which the measurement was performed.…”

Section: Fig 6 (Color Online)mentioning

confidence: 99%

“…The frequency response of the BM velocity magnitude and phase of the linearly tapered and uniform human cochlear models with a Q factor of 2.5, together with experimental measurements (Gundersen et al, 1978;Stenfelt et al, 2003) for the human cadaver. Frequencies are normalized by the best frequency, BF(x 0 ) % 1.2 kHz, at this level.…”

Section: Fig 8 (Color Online)mentioning

confidence: 99%

A linearly tapered box model of the cochlea

Sun

Elliott

2017

The Journal of the Acoustical Society of America

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A box shape with constant area is often used to represent the complex geometry in the cochlea, although variation of the fluid chambers areas is known to be more complicated. This variation is accounted for here by an “effective area,” given by the harmonic mean of upper and lower chamber area from previous measurements. The square root of this effective area varies linearly along the cochleae in the investigated mammalian species. This suggests the use of a linearly tapered box model in which the fluid chamber width and height are equal, but decrease linearly along its length. The basilar membrane (BM) width is assumed to increase linearly along the model. An analytic form of the far-field fluid pressure difference due to BM motion is derived for this tapered model. The distributions of the passive BM response are calculated using both the tapered and uniform models and compared with human and mouse measurements. The discrepancy between the models is frequency-dependent and becomes small at low frequencies. The tapered model developed here shows a reasonable fit to experimental measurements, when the cochleae are cadaver or driven at high sound pressure level, and provides a convenient way to incorporate cochlear geometrical variations.

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A Study of the Vibration of the Basilar Membrane in Human Temporal Bone Preparations by the Use of the Mossbauer Effect

Cited by 58 publications

References 7 publications

A summary of results in modeling plaque formation and development, cochlea mechanics and vestibular disorders

A summary of results in modeling plaque formation and development, cochlea mechanics and vestibular disorders

Electrophysiological Evidence of the Basilar-Membrane Travelling Wave and Frequency Place Coding of Sound in Cochlear Implant Recipients

A linearly tapered box model of the cochlea

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