A Study of the Secretory Nerves Of, and the Action of Certain Drugs On, the Prostate Gland

Farrell, James I.; Lyman, Yale

doi:10.1152/ajplegacy.1936.118.1.64

Cited by 33 publications

(13 citation statements)

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“…It remains undetermined whether such expulsion represents a simple squeezing out of fluid or a phenomenon accompanied by physiological glandular secretion. According to Farrell and Lyman (1937) and Smith (1968), the administration of pilocarpine caused a marked glandular secretion accompanied by contraction of the prostate. According to Ochiai (1953), glandular secretion was noted in re sponse to epinephrine administration.…”

Section: Discussionmentioning

confidence: 99%

A Histochemical Investigation of the Distribution of Adrenergic and Cholinergic Nerves in the Human Male Genital Organs

Shirai

Sasaki

Rikimaru³

1973

Tohoku J. Exp. Med.

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-A histochemical studies clarified the peripheral distribution of adrenergic and cholinergic nerves in the human male genital organs. In the human testis, there was a minimal distribu tion of catecholamine fluorescent fibers and acetylcholinesterase positive fibers around the blood vessels and in the interstitium. In the epididymis and the vas deferens, both nerve fibers were abundant in the muscle layer and interstitium. However, no difference in the distribution of these nerve fibers was noted according to the anatomical site of these organs. In the prostate, acetylcholinesterase positive fibers were abundant; but catecholamine fluorescent fibers were relatively few, and found in the interstitium and the muscle layer. These two types of nerve fibers were not found in the epithelial cell layer of the organs. catecho lamine; acetylcholinesterase; testis; epididymis; vas deferens; prostate Little is known about the innervation of the human male gential organs, especially of the testis, epididymis, vas deferens, prostate and penis, though the functions of these organs, i.e., spermatogenic function, ejaculation and erection are well known to be controlled by the nerves. There have been few histochemical studies on the distribution and course of the peripheral nerve supply to these organs.The silver staining method, which was used in the past for studies of the nervous system, is inadequate for accurate classification of the sympathetic and parasym pathetic peripheral nerve distribution in the genital organs.Recently, however, it has become possible to use catecholamine (CA) fluores cence as a histochemical index in order to demonstrate the distribution of adrenergic nerves. The distribution of cholinergic nerves has been demonstrated, using acetylcholinesterase (ACNE) as an index.The authors have already shown histochemically the localization of adrener gic and cholinergic nerves in the human penis . In the present study, the authors have demonstrated histochemically the localization of adrener-

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Section: Discussionmentioning

confidence: 99%

A Histochemical Investigation of the Distribution of Adrenergic and Cholinergic Nerves in the Human Male Genital Organs

Shirai

Sasaki

Rikimaru³

1973

Tohoku J. Exp. Med.

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“…The autonomic innervation plays a key role in regulation of male genital functions. Anatomical, pharmacological and physiological data (Hib, 1976;Laitinen and Talo, 1981;Pholpramool and Triphon, 1984;Mirabella et al, 2006Mirabella et al, , 2008Squillacioti et al, 2008Squillacioti et al, , 2009 suggest that the role of adrenergic and cholinergic inner- (Farrel and Lyman, 1937;Sjostrand, 1965;Mirabella et al, 2007) and blood flow (Baumgarten and Holstein, 1968;Kuwahara and Frick, 1974;Damber et al, 1982;Billups et al, 1990;Santamaria et al, 1995). Epithelial exo/endocytic events and ionic exchange between cellular and luminal compartments are other processes that are influenced by autonomic innervations (Mayerhofer et al, 1992;Chan et al, 1994;Kempinas et al, 1995;Lamano-Carvalho et al, 1996;Zhu et al, 1998).…”

Section: Innervation and Immunohistochemical Characteristics Of Epidimentioning

confidence: 99%

Innervation and Immunohistochemical Characteristics of Epididymis in Alpaca Camelid (Vicugna Pacos)

Liguori

Paino

Squillacioti

et al. 2013

Italian Journal of Animal Science

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Alpacas (Vicugna pacos) are domesticated camelids indigenous to south America and recently also bred in Europe and Italy for their high quality wool. There is little data available regarding the innervation of the male reproductive tract of this species. In the present study, the distribution of protein gene product 9.5 (PGP 9.5), neuropeptide Y (NPY), tyrosine hydroxilase (TH), calcitonin gene related peptide (CGRP) and substance P (SP) was analyzed in the epididymis by using immunohistochemical methods. Specimens of the caput, corpus and cauda epididymis were fixed in Bouin's fluid and processed for immunohistochemistry analysis with primary antibodies against PGP 9.5, NPY, TH, CGRP and SP. Immunopositivity to PGP 9.5 and TH and NPY was observed in nerve fibre bundles and in single nerve fibres contained into the peritubular connective tissue. Many TH and NPY immunopositive cells were found to innervate blood vessels. Rare CGRP and SP immunopositive nerves were observed. Several PGP 9,5 and NPY immunopositive epithelial cells were observed in the caput epididymis. The results of the present study suggest a role for the innervations in modulate reproductive functions in the alpaca epididymis.

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“…The role(s) of cholinergic nerves within the prostate gland remain uncertain, but participation of acetylcholine in prostatic secretory processes (Farrell & Lyman, 1937;Farnsworth & Lawrence, 1965), and of muscarinic receptors in mitogenic eects (Luthin et al, 1997;Rayford et al, 1997;McVary et al, 1998) have been proposed. The guinea-pig prostate gland, like that in the human (see Dail, 1993 for a review), contains acetylcholinesterase-positive nerve ®bres , which densely supplies the stroma as well as the acini of the gland.…”

Section: Introductionmentioning

confidence: 99%

Cholinergic facilitation of neurotransmission to the smooth muscle of the guinea‐pig prostate gland

Lau

Pennefather

Mitchelson

2000

British J Pharmacology

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1 Functional experiments have been conducted to assess the eects of acetylcholine and carbachol, and the receptors on which they act to facilitate neurotransmission to the stromal smooth muscle of the prostate gland of the guinea-pig. 2 Acetylcholine and carbachol (0.1 mM ± 0.1 mM) enhanced contractions evoked by trains of electrical ®eld stimulation (20 pulses of 0.5 ms at 10 Hz every 50 s with a dial setting of 60 V) of nerve terminals within the guinea-pig isolated prostate. In these concentrations they had negligible eects on prostatic smooth muscle tone. The facilitatory eects of acetylcholine, but not those of carbachol, were further enhanced in the presence of physostigmine (10 mM). 3 The facilitatory eects of carbachol were unaected by the neuropeptide Y Y 1 receptor antagonist BIBP 3226 ((R)-N 2 -(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-argininamide) (0.3 mM, n=3) or suramin (100 mM, n=5). Prazosin (0.1 mM, n=5) and guanethidine (10 mM, n=5) alone and in combination (n=4), reduced responses to ®eld stimulation and produced rightward shifts of the log concentration-response curves to carbachol. 4 The rank orders of potency of subtype-preferring muscarinic receptor antagonists in inhibiting the facilitatory actions of acetylcholine and carbachol were: pirenzepine 4 HHSiD (hexahydrosiladifenidol) 4 pF-HHSiD (para-¯uoro-hexahydrosiladifenidol) 5 himbacine, and pirenzepine 4 HHSiD 4 himbacine 5 pF-HHSiD, respectively. These pro®les suggest that muscarinic receptors of the M 1 -subtype mediate the facilitatory eects of acetylcholine and carbachol on neurotransmission to the smooth muscle of the guinea-pig prostate.

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A Study of the Secretory Nerves Of, and the Action of Certain Drugs On, the Prostate Gland

Cited by 33 publications

References 0 publications

A Histochemical Investigation of the Distribution of Adrenergic and Cholinergic Nerves in the Human Male Genital Organs

A Histochemical Investigation of the Distribution of Adrenergic and Cholinergic Nerves in the Human Male Genital Organs

Innervation and Immunohistochemical Characteristics of Epididymis in Alpaca Camelid (Vicugna Pacos)

Cholinergic facilitation of neurotransmission to the smooth muscle of the guinea‐pig prostate gland

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