A Study of the Quick Method for the Quantitative Determination of Prothrombin With Suggested Modifications

Observations on the Plasma Prothrombin and the Effects of Vitamin K in Patients With Liver or Biliary Tract Disease 1

“…The plasma prothrombin was measured quantitatively by a modified Quick method which has been described elsewhere (9). The prothrombin time was determined on 0.1 cc.…”

“…One-tenth cc. of an optimal calcium chloride solution (9) was added with a blow pipette, and the time required for coagulation after the addition of calcium was observed with a stop watch. With optimal recalcification the normal prothrombin time was 10 seconds (equivalent to 100 per cent).…”

“…With optimal recalcification the normal prothrombin time was 10 seconds (equivalent to 100 per cent). The prothrombin time was converted to the percentage concentration of plasma prothrombin with the aid of a graph previously described (9). The prothrombin was determined on normal plasma on each occasion to assure proper activity of the thromboplastin and the absence of calcium contamination of the glassware.…”

“…Numerous studies (5,6,7,8,9) indicate that a reduction in prothrombin is responsible for the hemorrhagic diathesis which some of these patients exhibit. Some investigators (3,8,10,11,12,13) conclude that the prothrombin deficiency, and the hemorrhagic state associated with it, can be corrected by the administration of preparations containing the fat-soluble antihemorrhagic vitamin K, with bile salts.…”

Diététique des affections veineuses des membres

“…Nous y avons déjà fait plus hau t allusion: l'alim entation, surtout chargée en lipides, est un facteur d'hypercoagulabilité. E n 1939 déjà, Pohle et Stewart notaient qu'un régime riche en graisses entraîne un raccourcissement de temps de Quick (13).…”