A Study of the Origin and Development of Lung Cancer

Raeburn, C.; Spencer, Herbert R.

doi:10.1136/thx.8.1.1

Cited by 108 publications

(25 citation statements)

References 7 publications

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“…Evidence in favour of this is that sarcoidosis involves the mucosa of the larger bronchi (Turiaf et al, 1952;Kalbian, 1957), and Raeburn and Spencer (1953) have demonstrated that malignant change may arise in postinflammatory scar tissue.…”

Section: Discussionmentioning

confidence: 99%

Bronchial Carcinoma and Sarcoidosis

Sakula¹

1963

Br J Cancer

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Section: Discussionmentioning

confidence: 99%

Bronchial Carcinoma and Sarcoidosis

Sakula¹

1963

Br J Cancer

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“…Our data are therefore similar to other studies, specifically that performed by Auerbach et al, [26] who found a lack of association between smoking and SC. A possible explanation is that atypical epithelial cells exist around some scars that later undergo unregulated proliferation with the development of metaplastic and then neoplastic cells, [40][41][42][43][44][45] which may occur irrespective of carcinogen exposure from smoking. There may be a genetic blueprint within a scar that gives it the ability to become neoplastic.…”

Section: Discussionmentioning

confidence: 99%

A 2-year retrospective review of the effect of cigarette smoking status on the histological cell types of lung carcinoma in the Western Cape

Pellizzon¹,

Koegelenberg²,

Irusen³

2015

S Afr Res J

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Background. Cigarette smoking is variably associated with the various histological cell types of lung cancer. The primary aim of this study was to analyse various strengths of association between the common histological cell types of lung cancer and smoking in a Western Cape population. The secondary aim examined whether an association exists between scar carcinoma and smoking. Methods. We retrospectively analysed the records from 386 patients over a 2-year period. Both smokers and non-smokers were subdivided and analysed as two groups, which included those with non-small cell and small cell lung cancer. Smokers and non-smokers were also analysed separately according to the presence or absence of lung scarring. Results. In total, 94.3% of all patients with lung cancer were current or past smokers. There was a disproportionately higher number of patients with adenocarcinoma who were non-smokers compared with all the other cell types (p=0.01), whereas patients with squamous cell carcinoma were more likely to be smokers (p=0.05). Although the vast majority of patients with and without lung scars were found to be smokers (96.4% v. 93.7% respectively), there was no statistically significant difference found between these two groups (p=0.43). Conclusion. In a Western Cape population, patients with adenocarcinoma were more likely to be non-smokers, while those with squamous cell carcinoma were relatively more likely to be smokers. No clear association between scar carcinoma and smoking status was found.

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“…In chronic repair in various sites malignancy sometimes eventually appears, and this is also true in interstitial lung disease (Raeburn & Spencer 1953 …”

Section: Interstitial Lung Diseaselmentioning

confidence: 99%

Interstitial Lung Disease

2010

Handbook of Disease Burdens and Quality of Life Measures

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A Study of the Origin and Development of Lung Cancer

Cited by 108 publications

References 7 publications

Bronchial Carcinoma and Sarcoidosis

Bronchial Carcinoma and Sarcoidosis

A 2-year retrospective review of the effect of cigarette smoking status on the histological cell types of lung carcinoma in the Western Cape

Interstitial Lung Disease

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