A Study of the Motility Patterns and the Basic Rhythm in the Duodenum and Upper Part of the Jejunum of Human Beings

Foulk, William T.; Code, Charles F.; Morlock, Carl G.; Bargen, J. Arnold

doi:10.1016/s0016-5085(54)80098-9

Cited by 72 publications

(11 citation statements)

References 10 publications

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“…These changes in PD were of two types: (1) small spikes (0 5 + 0 1 mV; mean ± SEM) which occurred at the same time as the pressure wave, but were relatively uncommon; (2) larger, more frequent 'waves' (3-1 ± 0.1 mV) with a peak-to-peak delay of 45 seconds and mean duration of two minutes. Discrete, simple type I pressure waves (Foulk et al, 1954) were very rarely associated with changes in the transmural PD. However, the infrequent pattern consisting of runs of type I waves, superimposed on a type III wave (basic rhythm, Foulk et al, 1954) was always found in association with the largest changes in PD (Figs.…”

Section: In Manmentioning

confidence: 92%

“…Discrete, simple type I pressure waves (Foulk et al, 1954) were very rarely associated with changes in the transmural PD. However, the infrequent pattern consisting of runs of type I waves, superimposed on a type III wave (basic rhythm, Foulk et al, 1954) was always found in association with the largest changes in PD (Figs. 3, 5, and 6).…”

Section: In Manmentioning

confidence: 92%

“…This type of activity was seen most clearly in patients with coeliac disease. Conversely, when the pressure record was particularly active, containing both type I and type III waves (Foulk et al, 1954) with few periods of quiescence, the electrical record exhibited larger and more frequent immediate PD spikes and less delayed PD waves. This type of record was observed most frequently in our normal subjects.…”

Section: In Manmentioning

confidence: 93%

“…Spontaneous PD fluctuations were for the most part associated with discrete multiphasic pressure complexes or type III waves (Foulk et al, 1954). These changes in PD were of two types: (1) small spikes (0 5 + 0 1 mV; mean ± SEM) which occurred at the same time as the pressure wave, but were relatively uncommon; (2) larger, more frequent 'waves' (3-1 ± 0.1 mV) with a peak-to-peak delay of 45 seconds and mean duration of two minutes.…”

Section: In Manmentioning

confidence: 99%

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Relationship between changes in intraluminal pressure and transmural potential difference in the human and canine jejunum in vivo.

Read¹,

Smallwood²,

Levin³

et al. 1977

Gut

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SUMMARY Recordings of transmural potential difference (PD) across the jejunum of conscious man in situ are characterised by spontaneous fluctuations of up to 10 mV. In 25 of 31 subjects (comprising seven normal controls and 24 patients under investigation for malabsorption, six of whom had coeliac disease) we observed a clear association between these fluctuations and changes in intraluminal pressure recorded at the same site. The most frequent PD changes were associated with type III pressure waves. These consisted predominantly of large waves (3.1 + 0 1 mV; mean + SEM, n = 317) which reached maximal amplitude approximately 45 seconds after the pressure peak and had a duration of 120 + 3 s, but also included less frequent spikes (0 5 + 0.1 mV; n = 110) concurrent with the pressure wave with a duration of 5 + 1 s. Although by recording at two sites in the jejunum 10 cm apart we were able to demonstrate that the type III pressure waves appeared to be propagated aborally at a median rate of 60 cm per minute, the apparent rates of propagation of the corresponding PD waves were much more variable. The largest PD changes (7i8 + 0 4 mV; n = 19), lasting several minutes, were found in association with runs of type I waves (basic rhythm) superimposed on a type III wave. Both pressure and PD activities were suppressed by intramuscular propantheline bromide. Intraluminal pilocarpine caused a transient rise in PD not always accompanied by a change in pressure. Distension of the jejunum by rapid injection of a bolus of isotonic sodium chloride produced a delayed rise in the PD which could be prevented by prior administration of propantheline bromide. Experiments usingThiryVella loops of proximal jejunum in conscious dogs confirmed the effect of jejunal distension on the PD and also demonstrated that spontaneous retching is preceded by an increase in the PD.Consideration of these results in conjunction with data from other workers suggests the hypothesis that the larger spontaneous fluctuations in transmural PD in the jejunum of conscious man are caused by changes in electrogenic secretion associated with intestinal motility and mediated by cholinergic mechanisms. The possible association of increased secretory activity with motility may have functions of lubrication as well as diluting and mixing the chyme for easier digestion and absorption.Several studies have noted that recordings of trans-changes have been a major obstacle to the investigamural PD in the human jejunum in situ are unstable tion of enterocyte transfer processes by electrical (Fordtran et al., 1968;Wingate et al., 1973; Read et methods. Our observation that propantheline al., 1974), being characterised by irregular fluctua-bromide (Pro-Banthine) inhibits these fluctuations tions which can last for several minutes and attain (Read et al., 1974; indicated that they may be amplitudes of 10 mV. These apparently spontaneous related to intestinal motility, which is also inhibited by this drug. We have investigated this possibility by pressure at the same site i...

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Section: In Manmentioning

confidence: 92%

Section: In Manmentioning

confidence: 92%

Section: In Manmentioning

confidence: 93%

Section: In Manmentioning

confidence: 99%

See 2 more Smart Citations

Relationship between changes in intraluminal pressure and transmural potential difference in the human and canine jejunum in vivo.

Read¹,

Smallwood²,

Levin³

et al. 1977

Gut

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show abstract

“…It has been demonstrated that the intraluminal pressure of the intestine is as high as 80 cmH 2 O in normal individuals. 8 On the other hand, the enteric wall which adhered to the dissected aorta in our patient underwent chronic inflammatory change due to mechanical stress from the aortic pressure. This resulted in increased thickening of the ilieac subserosa.…”

Section: Discussionmentioning

confidence: 70%

Primary aortoenteric fistula with a chronic isolated abdominal aortic dissection: Report of a case

et al. 1998

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A 47-year-old woman on long-term hemodialysis due to a chronic isolated abdominal aortic dissection was admitted to our department with severe abdominal pain. She had not suffered any hematemesis or melena. An emergency laparotomy revealed an abdominal aortic aneurysm with a diameter of 60mm, densely adhered to the ileum. An aortoenteric fistula manifesting as intramural rupture into the ileum was found after infrarenal abdominal aortic and bilateral common iliac cross-clamping. The fistula on the ileac side was nontransmural, but that on the aortic side communicated with the pseudolumen of the abdominal aorta, and contained mural thrombus. The infrarenal abdominal aorta and bilateral common iliac arteries were replaced with a collagen-sealed woven Dacron bifurcated graft. Histological examination of the ileum in this portion showed intramural bleeding and xanthomatous granulation with foam cell infiltration in the thickened subserosa. While it is difficult to diagnose nonpenetrating aortoenteric fistula preoperatively, such a fistula must be considered in a patient with severe abdominal pain, for whom previous abdominal aortic surgery has been performed or when an abdominal aneurysm is observed. To our knowledge, no other case of an aortoenteric fistula presenting as an intramural rupture into the ileum in an isolated abdominal aortic dissection has ever been reported.

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Early gastroduodenal motility following operation

Goodall¹

1964

British Journal of Surgery

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A Study of the Motility Patterns and the Basic Rhythm in the Duodenum and Upper Part of the Jejunum of Human Beings

Cited by 72 publications

References 10 publications

Relationship between changes in intraluminal pressure and transmural potential difference in the human and canine jejunum in vivo.

Relationship between changes in intraluminal pressure and transmural potential difference in the human and canine jejunum in vivo.

Primary aortoenteric fistula with a chronic isolated abdominal aortic dissection: Report of a case

Early gastroduodenal motility following operation

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