A study of the mechanical properties of fresh and preserved human femoral vein wall and valve cusps

Ackroyd, Jenny S.; Pattison, M.; Browse, N L

doi:10.1002/bjs.1800720216

Cited by 33 publications

(16 citation statements)

References 9 publications

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“…It has been demonstrated that the endothelial cells in the venous valve sinus behave differently from the ones in avalvular areas and have the ability to stretch twice as much [62]. Similar measurements have not been made in lymphatic valve sinuses; however, it is known that they are devoid of smooth muscle cells [14], which is likely to enable more extensive stretching of the vessel wall in this region.…”

Section: Valve Morphogenesismentioning

confidence: 99%

Flow control in our vessels: vascular valves make sure there is no way back

Bazigou

Mäkinen

2012

Cell. Mol. Life Sci.

112

107

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The efficient transport of blood and lymph relies on competent intraluminal valves that ensure unidirectional fluid flow through the vessels. In the lymphatic vessels, lack of luminal valves causes reflux of lymph and can lead to lymphedema, while dysfunction of venous valves is associated with venous hypertension, varicose veins, and thrombosis that can lead to edema and ulcerations. Despite their clinical importance, the mechanisms that regulate valve formation are poorly understood and have only recently begun to be characterized. Here, we discuss new findings regarding the development of venous and lymphatic valves that indicate the involvement of common molecular mechanisms in regulating valve formation in different vascular beds.

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Section: Valve Morphogenesismentioning

confidence: 99%

Flow control in our vessels: vascular valves make sure there is no way back

Bazigou

Mäkinen

2012

Cell. Mol. Life Sci.

112

107

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“…However, as far we know, before our study [7] about the Young's modulus and the Poisson's coefficient, there has been no specific research into live venous tissue and its surroundings in humans. These physical parameters have already been calculated by other authors [8,9], but only for non live venous tissue.…”

Section: Introductionmentioning

confidence: 97%

Calculation of Human Femoral Vein Wall Parameters In Vivo From Clinical Data for Specific Patient

Herrera¹,

Fortuny

Marimón

2012

Journal of Biomechanical Engineering

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A common problem in the elaboration of biomechanical models is determining the properties and characteristics (measures) of the physical behavior of in vivo tissues in the human body. Correct estimates must be made of the tissue's physical properties and its surroundings. We suggest a method to compute the constitutive modeling of venous tissue, for every specific patient, from clinically registered ultrasounds images. The vein is modeled as a hyperelastic, incompressible, thin-walled cylinder and the membrane stresses are computed using strain energy. The approach is based on a strain-energy function suggested by Holzapfel capturing the characteristic nonlinear anisotropic responses of femoral veins with its collagen fibers.

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“…In a previous study, preservation with buffered 1% glutaraldehyde did not significantly alter the mechanical properties related to the tensile strength of the vein wall (Ackroyd et al, 1985). To test for possible shrinkage due to chemical fixation and preservation in ethanol, we measured the inner circumference of three freshly-dissected veins prior to fixation, although unfixed veins could be more prone to measurement errors than fixed material owing to their soft-greasy consistency.…”

Section: Limitations Of This Studymentioning

confidence: 99%

Human Femoral Vein Diameter and Topography of Valves and Tributaries: A Post Mortem Analysis

et al. 2018

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The femoral vein (FV) is a clinically important vessel. Failure of its valves can lead to chronic venous insufficiency (CVI) with severe manifestations such as painful ulcers. Although they are crucial for identifying suitable implant sites for therapeutic valves, studies on the topography of FV tributaries and valves are rare. Moreover, the femoral vein diameter (FVD) must be known to assess the morphometric requirements for valve implants. To reassess the anatomical requirements for valve implants, 155 FVs from 82 human corpses were examined. FVDs and tributary and valve topographies were assessed using a laboratory straightedge. The FVD increased from 6 mm in the distal femoropopliteal vein to 11 mm in the iliofemoral vein proximal to the saphenofemoral junction (SFJ). Diameters were significantly bigger in males than females. Height correlated positively with FVD. Distal to the SFJ, within a distance of 38 cm, one to eight valves were present. Up to two valves were present within 10 cm proximal to the SFJ. Individual tributary and valve topography must be considered to ensure appropriate design and successful implantation of a venous valve for CVI therapy in the FV. A suitable implant site would be proximal to the SFJ via an infrainguinal transfemoral access. Clin. Anat. 31:1065–1076, 2018. © 2018 Wiley Periodicals, Inc.

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A study of the mechanical properties of fresh and preserved human femoral vein wall and valve cusps

Cited by 33 publications

References 9 publications

Flow control in our vessels: vascular valves make sure there is no way back

Flow control in our vessels: vascular valves make sure there is no way back

Calculation of Human Femoral Vein Wall Parameters In Vivo From Clinical Data for Specific Patient

Human Femoral Vein Diameter and Topography of Valves and Tributaries: A Post Mortem Analysis

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