A Study of the Lesion of Vitiligo

Gopinathan, T

doi:10.1001/archderm.1965.01600100113028

Cited by 28 publications

(13 citation statements)

References 16 publications

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“…Kaposi was the first to point out that the starting point of some vitiligo lesions could be caused by local conditions 18 . Several reports have subsequently shown that the Koebner phenomenon occurs in the majority of vitiligo patients 19–27 . In our experience, vitiligo vulgaris macules frequently appear at sites subjected to repeated mechanical traumas of various origins, e.g.…”

supporting

confidence: 56%

Melanocyte detachment after skin friction in non lesional skin of patients with generalized vitiligo

Gauthier¹,

Cario‐André²,

Lepreux³

et al. 2003

Br J Dermatol

160

106

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Detachment and transepidermal elimination of melanocytes following minor mechanical trauma in non lesional vitiligo skin is probably the cause of depigmentation occurring in the isomorphic response (Koebner phenomenon). We propose that transepidermal elimination of melanocytes in vitiligo should be regarded as a possible mechanism of chronic loss of pigment cells, perhaps previously damaged by another process.

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supporting

confidence: 56%

Melanocyte detachment after skin friction in non lesional skin of patients with generalized vitiligo

Gauthier¹,

Cario‐André²,

Lepreux³

et al. 2003

Br J Dermatol

160

106

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“…Hypomelanotic vitiligo lesions with poorly defined borders could be the clinical expression of the following histological features found at the margin: progressive depigmentation, epidermal changes (spongiosis and vacuolization of basal layers) 19–22 and inflammatory infiltrates. In ASBD lesions, it is easy to understand that this clinical aspect is likely to be related to sharp depigmentation and the absence of any epidermal or inflammatory change.…”

Section: Discussionmentioning

confidence: 99%

Clinical features and histological findings are potential indicators of activity in lesions of common vitiligo

Benzekri¹,

Gauthier²,

Hamada³

et al. 2012

British Journal of Dermatology

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“…Dutta [12], Gokhale et al [13] and Koga [14] confirmed that depigmented skin, especially in patients with segmental vit iligo, presented impaired neural influences. On the other hand, Gopinathan [15] found cutaneous perspiration and sweating to be unaltered in depigmented skin.…”

Section: Discussionmentioning

confidence: 99%

Normal-Range Plasma Catecholamines in Patients with Generalized and Acrofacial Vitiligo: Preliminary Report

et al. 1994

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Background: There is a body of evidence that neural factors may play a role in the pathogenesis of vitiligo. Objective: We look for the existence of a relationship between vitiligo and monoaminergic systems. Methods: We use high-pressure liquid chromatography to measure the plasma level of catecholamines, their precursor 3,4-dihydroxyphenylalanine and their metabolites 3-methoxy-4-hydroxy phenylglycol (MHPG), normetanephrine (NMN), metanephrine and homovanillic acid (HVA). Forty patients with the generalized (n = 31) and acrofacial (n = 9) types of vitiligo are studied. Results: Significant differences are not found either between males and females or between the entire group of patients and the controls. HVA and NMN levels significantly correlate with age (r = 0.332, p < 0.05, and r = 0.331, p < 0.05, respectively). Significant correlations are also seen either between noradrenergic or between dopaminergic parameters (norepinephrine vs. MHPG, r = 0.326, p < 0.05; dopamine vs. HVA, r = 0.540, p < 0.01). When the patients are grouped on the basis of vitiligo type or age of disease onset, the plasma mean levels of the neural compounds are always nonsignificantly different from those of the controls. However, both catecholamines and metabolites show higher, although not significant, concentrations in patients with a shorter duration of disease. Conclusion: Monoaminergic systems seem unlikely to be related to vitiligo, at least to the generalized and acrofacial types. However, variations cannot be excluded in genetically predisposed individuals during the onset or the active phases of disease.

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A Study of the Lesion of Vitiligo

Cited by 28 publications

References 16 publications

Melanocyte detachment after skin friction in non lesional skin of patients with generalized vitiligo

Melanocyte detachment after skin friction in non lesional skin of patients with generalized vitiligo

Clinical features and histological findings are potential indicators of activity in lesions of common vitiligo

Normal-Range Plasma Catecholamines in Patients with Generalized and Acrofacial Vitiligo: Preliminary Report

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