A Study of the LDH Level and the LDH Isoenzyme Pattern in Cantharidin Blister Fluid in Normal Skin and in Psoriasis

Grosfeld, J.C.M.; Mighorst, J.C.A.; Hartog, Beth; Ramshorst, A.G.S. van

doi:10.1159/000254075

Cited by 2 publications

(3 citation statements)

References 3 publications

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“…In contrast, the distribution patterns in fat tissue and the horny layer differ from those of epidermis and dermis; LDHS could not be detected in the horny layer (12). In a Discussion Serum and skin LDH levels have been measured in patients with various skin diseases (2)(3)(4)(5)(6)(7)(8); examples include cutaneous malignant and benign tumors, erythroderma, psoriasis vulgaris and viral infections. The association of high levels of serum LDH and liver metastases in advanced stage patients has been emphasized by several authors (10,11).…”

Section: Changes In Eo Ldh and Ige Levels In The Worsened Group (Tabmentioning

confidence: 99%

“…Monitoring of LDH can also provide useful information during the postoperative follow-up of patients with melanoma. In rubella infections (7), elevated LDH (94.3%) and its isoenzyme (LDH3) were observed during the early days, and therefore may be useful in early diagnosis. In addition, cases with elevated LDHS are significantly correlated with liver damage by rubella; range.…”

Section: Changes In Eo Ldh and Ige Levels In The Worsened Group (Tabmentioning

confidence: 99%

“…Isoenzyme analysis of LDH indicates the origin of elevated levels (1). Serum LDH levels have also been reported to be elevated in various skin diseases (2)(3)(4)(5)(6)(7)(8). Recent studies (3,4) suggested that serum LDH5 elevations in eczema-associated erythroderma were correlated with the epidermal cell damage.…”

Section: Introductionmentioning

confidence: 99%

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Significance of Elevated Serum LDH (Lactate Dehydrogenase) Activity in Atopic Dermatitis

Mukai

Noguchi

Kamimura

et al. 1990

The Journal of Dermatology

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Serum lactate dehydrogenase activity (LDH) was elevated in most cases with the severe type of atopic dermatitis (AD). We examined whether LDH correlated specifically with the clinical courses and the severity of AD skin eruptions. Blood eosinophil numbers (Eo), LDH and its isoenzymes, and serum IgE (IgE) levels in eighty patients with AD were measured before and after treatment. In improved groups, Eo and LDH decreased or returned to normal values after treatment. In contrast, both levels increased in patients who worsened after treatment. Thus changes in Eo and LDH correlated well with the clinical picture. However, IgE levels did not correlate with the clinical condition. High LDH levels were detected in the severe type of AD more frequently than in the mild type. A large majority of patients with elevated LDH (higher than 300 IU/l) before treatment had more severe skin eruptions. When the LDH before treatment was within normal limits, the LDH levels in improved patients showed a further decrease. Eo, LDH and IgE were correlated closely with the clinical scores of AD, and the relationship between LDH and clinical score was the highest. Elevations of LDH5 and LDH4 among the LDH isoenzymes were more prominent in the severe type of AD than in the mild type. We concluded that LDH was useful as a marker for evaluating the disease condition and severity of skin eruption of AD.

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Section: Changes In Eo Ldh and Ige Levels In The Worsened Group (Tabmentioning

confidence: 99%

Section: Changes In Eo Ldh and Ige Levels In The Worsened Group (Tabmentioning

confidence: 99%

See 1 more Smart Citation

Significance of Elevated Serum LDH (Lactate Dehydrogenase) Activity in Atopic Dermatitis

Mukai

Noguchi

Kamimura

et al. 1990

The Journal of Dermatology

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Pharmakologische Grundlagen der dermatologischen Therapie

Stüttgen

Schaefer

1974

Funktionelle Dermatologie

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A Study of the LDH Level and the LDH Isoenzyme Pattern in Cantharidin Blister Fluid in Normal Skin and in Psoriasis

Cited by 2 publications

References 3 publications

Significance of Elevated Serum LDH (Lactate Dehydrogenase) Activity in Atopic Dermatitis

Significance of Elevated Serum LDH (Lactate Dehydrogenase) Activity in Atopic Dermatitis

Pharmakologische Grundlagen der dermatologischen Therapie

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