A study of the enantiospecific degradation of ibuprofen in model aqueous samples using LLME-HPLC-DAD

Magiera, Sylwia; Piwowarczyk, Aleksanda; Węgrzyn, Anna

doi:10.1039/c6ay02670b

Cited by 8 publications

(5 citation statements)

References 26 publications

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“…For the ( R )‐IBP, the LOD and LOQ were even more impressive at LOD = 1.60 × 10 −11 mol and LOQ = 4.85 × 10 −11 mol, showcasing the method's exceptional analytical capabilities. The chromatographic separation of IBP enantiomers was achieved using a Chiralcel® OJ‐RH column, and the mobile phase consisted of 0.05% trifluoroacetic acid in a mixture of water and acetonitrile (65:35, v/v) 40 . The detection of the enantiomers occurred at 220 nm.…”

Section: Methods For Stereoselective Analysis Of Ibuprofenmentioning

confidence: 99%

“…The chromatographic separation of IBP enantiomers was achieved using a Chiralcel ® OJ-RH column, and the mobile phase consisted of 0.05% trifluoroacetic acid in a mixture of water and acetonitrile (65:35, v/v). 40 The detection of the enantiomers occurred at 220 nm. The method demonstrated excellent linearity for both enantiomers, with a concentration range of 0.02-2 μg mL À1 and correlation coefficients ranging from 0.9951 to 0.9953.…”

Section: Liquid Chromatographymentioning

confidence: 99%

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Enantioselective separation and determination of ibuprofen: Stereoselective pharmacokinetics, pharmacodynamics and analytical methods

Vashistha,

Kumar,

Yadav

et al. 2024

Chirality

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Ibuprofen (IBP), the 29th most prescribed drug in the United States in 2019, is a widely used nonsteroidal anti‐inflammatory drug (NSAID) comprising two enantiomers, (R)‐IBP and (S)‐IBP, collectively known as (RS)‐IBP. This critical review examines analytical techniques for the enantioselective separation and determination of IBP enantiomers, crucial for pharmaceutical and clinical applications. The review focuses on state‐of‐the‐art methods, including chromatographic techniques including high‐performance liquid chromatography, gas chromatography, liquid chromatography–tandem mass spectrometry, and some other techniques. This review addresses pharmacokinetics, pharmacology, and side effects of each enantiomer, ensuring safe drug usage. By consolidating diverse analytical methods and their applicability in different matrices, this review serves as a valuable resource for researchers, analysts, and practitioners in pharmaceutical analysis, pharmacology, and clinical studies.

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Section: Methods For Stereoselective Analysis Of Ibuprofenmentioning

confidence: 99%

Section: Liquid Chromatographymentioning

confidence: 99%

Enantioselective separation and determination of ibuprofen: Stereoselective pharmacokinetics, pharmacodynamics and analytical methods

Vashistha,

Kumar,

Yadav

et al. 2024

Chirality

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show abstract

“…Quantification of PTX and IBU was performed at 220 nm. − For PTX, within the first 10 min, the proportion of ACN was increased from 40% to 60%. Solvent proportion was kept constant for 5 min prior to decreasing it to the initial proportion of 40% ACN within 0.5 min.…”

Section: Methodsmentioning

confidence: 99%

Synthesis and Investigation of Chiral Poly(2,4-disubstituted-2-oxazoline)-Based Triblock Copolymers, Their Self-Assembly, and Formulation with Chiral and Achiral Drugs

Yang¹,

Haider²,

Forster³

et al. 2022

Macromolecules

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Considering the largely chiral nature of biological systems, there is interest in chiral drug delivery systems. Here, we investigate for the first time polymer micelles based on poly(2-oxazoline) (POx) ABA-type triblock copolymers with chiral and racemic hydrophobic blocks for the formulation of chiral and achiral drugs. Specifically, poly(2-ethyl-4-ethyl-2oxazoline) (pEtEtOx) and poly(2-propyl-4-methyl-2-oxazoline) (pPrMeOx) were used as hydrophobic block B and poly(2-methyl-2-oxazoline) (pMeOx) as hydrophilic block A. Using these triblock copolymers, nanoformulations of curcumin (CUR), paclitaxel (PTX), and chiral (R and S) and racemic ibuprofen were prepared. For CUR and PTX, the maximum drug loading was significantly dependent on the structure of the hydrophobic repeat units, but not the chirality. In contrast, the maximum drug loading with chiral/racemic ibuprofen was affected neither by the polymer structure nor by chirality, but minor effects were observed with respect to the size and size distribution of the drug-loaded micelles.

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“…Quantification of paclitaxel (PTX) and ibuprofen (IBU) was performed at 220 nm. [48][49][50] For PTX, within the first 10 min, the proportion of ACN was increased from 40% to 60%. Solvent proportion was kept constant for 5 min prior to decrease it to initial proportion of 40% ACN within 0.5 min.…”

Section: Uv-vis Spectroscopy Cur Quantification Was Performed By Uv-vis Absorption On a Biotek Eon Microplatementioning

confidence: 99%

Synthesis and investigation of chiral poly(2,4-disubstituted-2-oxazoline) based triblock copolymers, their self-assembly and formulation with chiral and achiral drugs

Yang

Haider

Forster

et al. 2022

Preprint

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Considering the largely chiral nature of biological systems, there is interest in chiral drug delivery systems. Here, we investigate for the first time polymer micelles based on poly(2-oxazoline)s (POx) ABA-type triblock copolymers with chiral and racemic hydrophobic blocks for the formulation of chiral and achiral drugs. Specifically, poly(2-ethyl-4-ethyl-2-oxazoline) (pEtEtOx) and poly(2-propyl-4-methyl-2-oxazoline) (pPrMeOx) were used as hydrophobic block B and poly(2-methyl-2-oxazoline) (pMeOx) as hydrophilic block A. Using these triblock copolymers, nanoformulations of curcumin (CUR), paclitaxel (PTX) as well as chiral (R and S) and racemic ibuprofen were prepared. For CUR and PTX, the maximum drug loading dependent significantly on the structure of the hydrophobic repeat units, but not the chirality. In contrast, the maximum drug loading with chiral/racemic ibuprofen was neither affected by the polymer structure nor by chirality, but minor effects were observed with respect to the size and size distribution of the drug loaded micelles.

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A study of the enantiospecific degradation of ibuprofen in model aqueous samples using LLME-HPLC-DAD

Abstract: Liquid–liquid microextraction (LLME) by high-performance liquid chromatography-diode array detection (HPLC-DAD) is a simple, rapid, efficient and environmentally friendly method that was developed to determine enantiomers of ibuprofen in aqueous environmental samples.

Cited by 8 publications

References 26 publications

Enantioselective separation and determination of ibuprofen: Stereoselective pharmacokinetics, pharmacodynamics and analytical methods

Enantioselective separation and determination of ibuprofen: Stereoselective pharmacokinetics, pharmacodynamics and analytical methods

Synthesis and Investigation of Chiral Poly(2,4-disubstituted-2-oxazoline)-Based Triblock Copolymers, Their Self-Assembly, and Formulation with Chiral and Achiral Drugs

Synthesis and investigation of chiral poly(2,4-disubstituted-2-oxazoline) based triblock copolymers, their self-assembly and formulation with chiral and achiral drugs

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