A study of the effect of betahistine on gastric acid secretion in man

Km, Cochran; Jg, Allan; Ri, Russell

doi:10.1185/03007997409114246

Cited by 1 publication

(2 citation statements)

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“…CURWAIN et al [7] demonstrated that betahistine increased both gastric mucosal blood flow and gastric acid secretion from the Heidenhein pouch of the dog. In contrast, COCr~-RAN et alo [18] failed to demonstrate an increase in gastric acid secretion induced by betahistine in man. In the experiments of COCrIRAN et al [18] the concentration of betahistine was high and produced headache and flushing in five of the six subjects and hence it is possible that the H1 sideeffects limited the dose that could be given in these experiments.…”

Section: Drug and Concentration (/~M)mentioning

confidence: 85%

“…In contrast, COCr~-RAN et alo [18] failed to demonstrate an increase in gastric acid secretion induced by betahistine in man. In the experiments of COCrIRAN et al [18] the concentration of betahistine was high and produced headache and flushing in five of the six subjects and hence it is possible that the H1 sideeffects limited the dose that could be given in these experiments. If betahistine has less potency at H2 receptors than histamine, the dose reached in these studies was probably insufficient to activate the H2 receptors mediating gastric acid secretion.…”

Section: Drug and Concentration (/~M)mentioning

confidence: 85%

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Some studies of the action of betahistine at H1 and H2 receptors for histamine

et al. 1986

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Betahistine produced a concentration-dependent contraction of the guinea-pig ileum and was about 27 times less active than histamine in this respect. Betahistine induced desensitization of contractile responses to histamine in the guinea-pig ileum. The H1 histamine receptor antagonist mepyramine was a competitive antagonist of the action of betahistine on the guinea-pig ileum. Betahistine caused relaxation of the rat uterus contracted by acetylcholine, and this action of betahistine was blocked by the H2 receptor antagonist cimetidine. Betahistine had a concentration-dependent positive chronotropic action on isolated guinea-pig atria, and in this respect was tenfold less potent than histamine. The action of betahistine on the atria was blocked by the H2 receptor antagonist YM11170. Betahistine caused a concentration-related contraction of the isolated lung parenchymal strip of the guinea-pig, and YM11170 potentiated this effect. Betahistine failed to release histamine from rat peritoneal mast cells at concentrations up to 100 microM and it did not prevent histamine release induced by either substance P or anti-IgE. Betahistine produced a dose-related flare and wheal reaction when injected intradermally into human skin. It is concluded that betahistine has agonist activity at both H1 and H2 receptors for histamine.

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Section: Drug and Concentration (/~M)mentioning

confidence: 85%

Section: Drug and Concentration (/~M)mentioning

confidence: 85%