A study of the effect of setup errors and organ motion on prostate cancer treatment with IMRT

Landoni, V.; Saracino, Bianca; Marzi, Simona; Gallucci, Michele; Petrongari, Maria Grazia; Chianese, Enrico; Benassi, M.; Iaccarino, Giuseppe; Soriani, A.; Arcangeli, Giorgio

doi:10.1016/j.ijrobp.2006.01.021

Cited by 48 publications

(24 citation statements)

References 30 publications

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“…Image guidance or fiducial markers were not available at study initiation. However, in a previous study by our group (22), the prostate motion in all directions was shown to be not >6 mm. Thus, because that was within the PTV margins planned in the present study, the accuracy of the set up was monitored by daily verifying the isocenter position with respect to that using digitally reconstructed radiographs from orthogonal portal images.…”

Section: Simulation and Treatmentmentioning

confidence: 63%

Acute and Late Toxicity in a Randomized Trial of Conventional Versus Hypofractionated Three-Dimensional Conformal Radiotherapy for Prostate Cancer

Arcangeli¹,

Fowler

Gomellini³

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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142

100

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Section: Simulation and Treatmentmentioning

confidence: 63%

Acute and Late Toxicity in a Randomized Trial of Conventional Versus Hypofractionated Three-Dimensional Conformal Radiotherapy for Prostate Cancer

Arcangeli¹,

Fowler

Gomellini³

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

Self Cite

142

100

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“…On the other hand, the routine use of radiobiological models for NTCP calculation has not been established yet. Nowadays, NTCP use is limited to studies about plan ranking [25], technique comparison [5,34], and evaluation of treatment efficacy and toxicity [31,41]. Efforts have been made to study organ response to radiation and, consequently, to try to establish new parameters [7,42].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of late rectal toxicity after conformal radiotherapy for prostate cancer

et al. 2009

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“…Similarly, Hatton et al (7) also observed the difference in bladder and rectal volumes and doses in patients undergoing prostate radiotherapy. Landoni et al (8) have also studied the effect of setup errors and organ motion on prostate cancer IMRT and the results have proved that though rectum dose is very different than planned, it has negligible effect on prostate dose coverage.…”

Section: Introductionmentioning

confidence: 99%

Dosimetric and volumetric changes in the rectum and bladder in patients receiving CBCT‐guided prostate IMRT: analysis based on daily CBCT dose calculation

Pearson

Gill

Campbell

et al. 2016

J Applied Clin Med Phys

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Delivered dose can be calculated by transferring the planned treatment beams onto the daily CBCT. Bladder and rectum volumetric doses were calculated and correlated to the daily bladder and rectum fullness. Patients for this study underwent hypofractionated prostate IMRT to 70 Gy in 28 fractions. Daily CBCT was utilized for image guidance. A clinically acceptable plan was created using a CTV‐to‐PTV uniform margin of 5 mm. Image fusion was performed to transfer the bladder and rectum contours onto each CBCT. Contours were then edited to match the anatomy of each CBCT. Using the daily treatment isocenter, the planned beams were transferred onto the CBCT and daily and cumulative DVHs calculated. For the results a total of 168 daily CBCTs were evaluated. The bladder was found to be smaller for 74.7% of the 168 daily CBCTs accessed in this study. This reduction in volume correlated to an increase in the cumulative bladder V70 Gy from 9.47% on the planning CT to 10.99% during treatment. V70Gy for the rectum was 7.27% on the planning CT, when all six patients were averaged, and increased to 11.56% on the average of all daily treatment CBCTs. Increases in volumetric rectum dose correlated with increases in rectal volume. For one patient, the rectum and bladder absolute V70 Gy, averaged over the course of treatment, increased by 295% and 61%, respectively. Larger variations in the daily bladder and rectal volume were observed and these correlated to large deviations from the volumetric dose received by these structures. In summary, bladder and rectum volume changes during treatment have an effect on the cumulative dose received by these organs. It was observed that the volumetric dose received by the bladder decreases as the volume of the bladder increases. The inverse was true for the rectum.PACS number(s): 87.55.dk‐, 87.57.Q‐

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A study of the effect of setup errors and organ motion on prostate cancer treatment with IMRT

Cited by 48 publications

References 30 publications

Acute and Late Toxicity in a Randomized Trial of Conventional Versus Hypofractionated Three-Dimensional Conformal Radiotherapy for Prostate Cancer

Acute and Late Toxicity in a Randomized Trial of Conventional Versus Hypofractionated Three-Dimensional Conformal Radiotherapy for Prostate Cancer

Evaluation of late rectal toxicity after conformal radiotherapy for prostate cancer

Dosimetric and volumetric changes in the rectum and bladder in patients receiving CBCT‐guided prostate IMRT: analysis based on daily CBCT dose calculation

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