A study of the distribution of aluminium in human placental tissues based on alkaline solubilization with determination by electrothermal atomic absorption spectrometry

Kruger, Pamela C.; Schell, Lawrence M.; Stark, Alice D.; Parsons, Patrick J.

doi:10.1039/c0mt00010h

Cited by 13 publications

(12 citation statements)

References 53 publications

(80 reference statements)

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“…The linear regression best fit slope of the placental Al concentrations is greater than the slope of the fetal Al concentrations, further indicating greater Al distribution into the placenta than fetus. Similarly, a study that quantified Al in the placental body and membrane and umbilical cord found less Al in the cord (0.56 and 0.53 versus 0.27, respectively) (Kruger et al 2010). A normally distributed transform of the testes Al concentration as a multiple of the Al concentration in animals that did not receive additional Al (Table 10) was not identified.…”

Section: (2262)mentioning

confidence: 93%

Aluminum reproductive toxicity: a summary and interpretation of scientific reports

Yokel

2020

Critical Reviews in Toxicology

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Publications addressing aluminum (Al)-induced reproductive toxicity were reviewed. Key details were compiled in summary tables. Approximate systemic Al exposure, a measure of bioavailability, was calculated for each exposure, based on the Al percentage in the dosed Al species, Al bioavailability, and absorption time course reports for the exposure route. This was limited to laboratory animal studies because no controlled-exposure human studies were found. Intended Al exposure was compared to unintended dietary Al exposure. The considerable and variable Al content of laboratory animal diets creates uncertainty about reproductive function in the absence of Al. Aluminum-induced reproductive toxicity in female mice and rats was evident after exposure to !25-fold the amount of Al consumed in the diet. Generally, the additional daily Al systemic exposure of studies that reported statistically significant results was greater than 100-fold above the typical human daily Al dietary consumption equivalent. Male reproductive endpoints were significantly affected after exposure to lower levels of Al than females. Increased Al intake increased fetus, placenta, and testes Al concentrations, to a greater extent in the placenta than fetus, and, in some cases, more in the testes than placenta. An adverse outcome pathway (AOP) was constructed for males based on the results of the reviewed studies. The proposed AOP includes oxidative stress as the molecular initiating event and increased malondialdehyde, DNA and spermatozoal damage, and decreased blood testosterone and sperm count as subsequent key events. Recommendations for the design of future studies of reproductive outcomes following exposure to Al are provided.

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Section: (2262)mentioning

confidence: 93%

Aluminum reproductive toxicity: a summary and interpretation of scientific reports

Yokel

2020

Critical Reviews in Toxicology

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“…High concentration of Al in human semen as well as the presence of Al in spermatozoa have been reported in patients with deteriorated semen quality, which suggests possible implications of Al in spermatogenesis and sperm count [ 16 ]. An analytical study on placenta tissues showed that Al was present in 95% of placenta body samples and 81% of placenta membrane samples, but only in 46% of umbilical cord samples, which indicates that the placenta acts as a partial barrier to Al exposure in utero [ 17 ]. The authors concluded that the developing fetus may still be vulnerable to cumulative Al exposure and that it is, therefore, important to establish reference ranges for Al levels in placental tissues [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…An analytical study on placenta tissues showed that Al was present in 95% of placenta body samples and 81% of placenta membrane samples, but only in 46% of umbilical cord samples, which indicates that the placenta acts as a partial barrier to Al exposure in utero [ 17 ]. The authors concluded that the developing fetus may still be vulnerable to cumulative Al exposure and that it is, therefore, important to establish reference ranges for Al levels in placental tissues [ 17 ]. Exposure to toxic metals including Al has been recently investigated as a potential cause of miscarriages [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Prenatal Exposure to Aluminum and Status of Selected Essential Trace Elements in Rural South African Women at Delivery

Röllin

Nogueira

Olutola

et al. 2018

IJERPH

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This study sought to evaluate the in utero exposure to aluminum and status of selected trace elements in South African women at delivery since aluminum is known to be toxic in all developmental stages even at low concentrations. Serum aluminum was negatively correlated with aluminum in urine, both uncorrected and corrected for creatinine, which suggests the retention of aluminum in body stores. Serum copper and zinc levels were found to be high in this study population. Serum copper levels were negatively correlated with aluminum in serum (β = −0.095; p = 0.05). There was a marginal negative correlation between aluminum levels in serum and manganese levels in whole blood (β = −0.087; p = 0.08). Copper levels in maternal serum were negatively correlated with birth weight and the length of neonates. There were a number of positive correlations between maternal characteristics and birth outcomes. Mothers who consumed root vegetables frequently appeared to be protected from aluminum retention and increased body burden since their serum aluminum levels were found to be significantly lower. The findings of the current study can be used as a baseline for further research on aluminum exposure and its associated interactions and outcomes in vulnerable populations.

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“…The SPH students have been first authors on numerous DOH/SPH studies published jointly, including an MCH-funded study related to the control of rabies risk in children, 19 and a collaborative environmental health article selected as the journal's cover page. 20 In addition to the benefits to research and program evaluation, the opportunity to teach and be involved in an academic environment increases the DOH's ability to recruit, retain, and improve the skill level of its professional and scientific staff. A skilled professional workforce improves the DOH's ability to assess health problems and to design and evaluate public health programs in the state.…”

Section: • Benefits Of the Ahd Model To The Doh And Public Health In mentioning

confidence: 99%

Integrating Public Health Education in a Public Health Practice Setting

Birkhead

Eidson

Dewar

et al. 2014

Journal of Public Health Management and Practice

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The New York State Department of Health (DOH) has a long history of biomedical research, public health policy and program development, peer-reviewed scholarship, and teaching. Its evolution as an academic health department advanced significantly when the University at Albany and DOH formed the School of Public Health Sciences in 1985 to further develop these functions while formally training the next generation of public health workers. The School, renamed in 1990 as the School of Public Health (SPH), was initially located within the DOH with its staff as the founding faculty. The curriculum was heavily influenced by public health practice imperatives. The SPH has evolved to have an independent campus and full-time academic faculty, but the DOH remains closely linked. The relationship is governed by a memorandum of understanding that commits both partners to provide substantial and continuing resources to the SPH. The SPH brings value to the DOH's mission to improve the health of the state's citizens by providing an academic focus to problems faced in health department practice settings. The opportunity to teach and be involved in an academic environment increases the DOH's ability to recruit, retain, and improve the skill level of its professional and scientific staff and thereby improve its ability to assess health problems and to design and evaluate public health programs. The SPH also provides training and support to county health departments and nongovernment organizations, which further the DOH's mission, through continuing education programs and an online MPH degree program. International exchanges including those with China, Vietnam, and the Republic of Georgia have enriched the academic environment. Challenges include maintaining sufficient full-time faculty members, the need for the SPH to take on broader public health issues than those applicable to New York, and the shrinkage of the DOH's workforce and departure of many senior scientists who served as faculty.

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A study of the distribution of aluminium in human placental tissues based on alkaline solubilization with determination by electrothermal atomic absorption spectrometry

Cited by 13 publications

References 53 publications

Aluminum reproductive toxicity: a summary and interpretation of scientific reports

Aluminum reproductive toxicity: a summary and interpretation of scientific reports

Prenatal Exposure to Aluminum and Status of Selected Essential Trace Elements in Rural South African Women at Delivery

Integrating Public Health Education in a Public Health Practice Setting

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