A study of the distribution and retention of cadmium-115 in the albino rat

Decker, C. F.; Byerrum, Richard U.; Hoppert, C.A.

doi:10.1016/0003-9861(57)90544-1

Cited by 95 publications

(19 citation statements)

References 3 publications

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“…The uptake pattern, following s.c. injection, in the domestic fowl testis, muscle and liver is very similar to that found in the rat in this study and to that previously reported in the rat by Johnson & Miller (1970). The relative distribution in these tissues in general is in harmony with previous work for later sampling times in the rat (Decker, Byerrum & Hoppert, 1957;Friberg & Odeblad, 1957), mouse (Cotzias, Borg & Selleck, 1961a;Berlin & Ullberg, 1963;Gunn, Gould & Anderson, 1968), dog (Walsh & Burch, 1959), goat (Miller, Blackmon & Martin, 1968) and calf (Powell, Miller, Morton & Clifton, 1964 (Gunn et al, 1968), while Zn decreased Cd uptake by testes. At first (Text- fig.…”

Section: Discussionsupporting

confidence: 79%

Early Actions of Cadmium in the Rat and Domestic Fowl Testis

Ad¹,

Mb²,

Wj³

1970

Reproduction

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Section: Discussionsupporting

confidence: 79%

Early Actions of Cadmium in the Rat and Domestic Fowl Testis

Ad¹,

Mb²,

Wj³

1970

Reproduction

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“…Interestingly, the oral/ intraperitoneal dose ratio is about 100/1, a value which correlates well with the observation that only 1-2% of an oral cadmium dose is absorbed (18). Our findings with oral cadmium administration differ from the data of Kotsonis and Klaassen (19), who administered cadmium chloride orally in doses ranging from 0 to 150 mg Cd/kg but found no alterations in microsomal cytochrome P-450 content or aniline hydroxylase activity at 2 or 4 days after cadmium.…”

Section: Inhibition Of Hepatic Microsomal Drug Metabolism By Cadmiumsupporting

confidence: 58%

“…Hexobarbital metabolism was measured in hepatic microsomes as described. Adapted from Schnell et al (18).…”

Section: Tolerance To the Cadmium-induced Inhibitory Effectsmentioning

confidence: 99%

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Studies on Cadmium-Induced Inhibition of Hepatic Microsomal Drug Biotransformation in the Rat

Schnell¹,

Means²,

Roberts³

et al. 1979

Environmental Health Perspectives

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Cadmium is a potent inhibitor of hepatic microsomal drug biotransformation in the rat. Male rats receiving a single intraperitoneal dose of cadmium exhibit significant decreases in hepatic microsomal metabolism of a variety of substrates. The threshold cadmium dose is 0.84 mg Cd/kg, and the effect lasts at least 28 days. Mechanistically, the inhibitory effect results from decreased cytochrome P450 content since cadmium does not alter NADPH cytochrome c reductase activity. This effect is also observed following acute oral administration of cadmium in doses greater than 80 mg Cd/kg but is not observed following chronic administration of the metal via drinking water in concentrations of 5-200 ppm for periods ranging from 2 to 50 weeks. A tolerance to the inhibitory cadmium effect is observed if male rats are pretreated with subthreshold doses of the metal prior to the challenge cadmium dose. The degree of tolerance can be overcome by increasing the challenge dose of cadmium. Characterization of the tolerance phenomenon in terms of onset, duration, and intensity reveals a good correlation with the kinetics of metaliothionein production, suggesting that the underlying basis for the tolerance phenomenon is likely the induction of metallothionein. A sex-related difference in the inhibitory effect of cadmium was observed. Cadmium did not inhibit the metabolism of hexobarbital or ethylmorphine in female rats but did inhibit that of aniline or zoxazolamine. Cadmium did not lower cytochrome P-450 content in female rats.

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“…The only study that provides any information indicates that 30 days following oral administration of an oral dose of 115Cd, the rate of fecal excretion was approximately half the rate of urinary excretion (111). There also is some evidence for excretion through the intestinal tract into the feces following parenteral injection in rats (112). In man there is a slight but statistically significant increase in cadmium excretion in the urine with age (180).…”

Section: Metabolism Of Cadmiummentioning

confidence: 99%