A study of the cyanogenetic content and toxicity of the fruit of selected species ofCotoneaster

Tidwell, Robert H.; Beal, Jack L.; Patel, D. G.; Tye, A.; Patil, Popat N.

doi:10.1007/bf02860634

Cited by 6 publications

(4 citation statements)

References 3 publications

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“…The toxicity of Cotoneaster fruits was then evaluated in in vivo studies conducted on a group of rats, administered by C. divaricatus fruits at doses of 0.5, 1.0, 2.0, and 4.0 g/kg body weight. The fruits at a dose of 0.5 g/kg were completely safe for the rats; the first symptoms of cyanide toxicity were observed at a dose of 1 g/kg [ 36 ].…”

Section: Phytochemical Composition Of the Genus Cotoneasmentioning

confidence: 99%

An Overview of the Genus Cotoneaster (Rosaceae): Phytochemistry, Biological Activity, and Toxicology

Kicel

2020

Antioxidants

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Traditional herbal medicines have become a subject of global importance with both medical and economic implications. The regular consumption of herbal drugs has led to serious concerns regarding their quality, effectiveness, and safety. Thus, relevant scientific evidence has become an important criterion for the acceptance of traditional health claims. The genus Cotoneaster Medikus provides numerous species traditionally used in Asian medicine for the treatment of haemorrhoids, diabetes, and cardiovascular diseases. This review summarises the achievements of modern research on the Cotoneaster taxa, including ethnobotany, phytochemistry, pharmacology, and toxicology. To date, more than 90 compounds have been isolated or analytically identified in Cotoneaster leaves, fruits, flowers or twigs. These phytochemicals are categorised into flavonoids, procyanidins, phenolic acids, cotonefurans, cyanogenic glycosides, triterpenes, sterols, fatty acids, volatile compounds, and carbohydrates, and many of them are responsible for Cotoneaster pharmacological properties including antioxidant, anti-inflammatory, antimicrobial, antiparasitic, hepatoprotective, anti-diabetic or anti-dyslipidaemic activity. In order to ensure the safety of pharmaceutical applications, the potential toxicity of Cotoneaster extracts has also been investigated. In conclusion, this systematic review provides an important reference base for further study into the various medical applications of both the dry extracts and pure isolates of Cotoneaster species.

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Section: Phytochemical Composition Of the Genus Cotoneasmentioning

confidence: 99%

An Overview of the Genus Cotoneaster (Rosaceae): Phytochemistry, Biological Activity, and Toxicology

Kicel

2020

Antioxidants

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“…To the author's knowledge, this is the first report of Cotoneaster poisoning in animals. Previous investigators have identified cyanogenic glycosides in this plantspecies 1,16 . Prunasin occurs in the leaves and fruits, but amygdalin only occurs in fruits 10 of this plant.…”

mentioning

confidence: 90%

“…Previous investigators have identified cyanogenic glycosides in this plant species. 1,16 Prunasin occurs in the leaves and fruits, but amygdalin only occurs in fruits 10 of this plant. Seasonal variation in cyanogenic glycoside content exists, with greater quantities of these toxins occurring during rapid growth of the plant.…”

mentioning

confidence: 99%

“…Like Prunus laurocerasus and other plants from the Rosaceae family, Cotoneaster sp. can contain cyanogenic glycosides, but this genus has never been described before, to our knowledge, as a cause of poisoning in animals 16 . A 2.5-year-old llama ( Lama glama L.) belonging to a circus was admitted to the Exotic Pets and Wildlife Clinic (National Veterinary School, Toulouse, France).…”

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Cotoneaster sp. Poisoning in a Llama (Lama Glama)

Grüss

Priymenko

2009

J VET Diagn Invest

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Abstract. A case of poisoning with a Cotoneaster sp. is described in a llama (Lama glama). The clinical signs were dyspnea, with congested mucous membranes, chewing, recumbency, and opisthotonos. Several hours after ingestion of the plant, the llama died, despite treatment with sodium thiosulfate and nitrite. Necropsy revealed approximately 676 g of leaves and fruit of Cotoneaster in the first compartment of the stomach. The blood was light red and did not clot. Because Cotoneaster sp. contains low concentrations of cyanogenic glycosides, toxicosis occurs only following massive ingestion of plant material.

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Cotoneaster Species

and¹,

Chapman²

2000

Handbook of Poisoning in Dogs and Cats

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A study of the cyanogenetic content and toxicity of the fruit of selected species ofCotoneaster

Cited by 6 publications

References 3 publications

An Overview of the Genus Cotoneaster (Rosaceae): Phytochemistry, Biological Activity, and Toxicology

An Overview of the Genus Cotoneaster (Rosaceae): Phytochemistry, Biological Activity, and Toxicology

Cotoneaster sp. Poisoning in a Llama (Lama Glama)

Cotoneaster Species

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