A study of the correlation between obesity and intestinal flora in school-age children

Gao, Xiaolin; Jia, Ruizhen; Xie, Liyang; Kuang, Linghan; Feng, Ling; Wan, Chaomin

doi:10.1038/s41598-018-32730-6

Cited by 45 publications

(44 citation statements)

References 24 publications

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“…The results α diversity analysis showed no significant difference between the control group and the antibiotic exposure group; however, the β diversity analysis showed significant differences in the structure of two groups of bacteria, which was consistent with the results [7].…”

Section: The Colonization Of Different Gut Microbiota Participate In Weight Changes Of Offspringsupporting

confidence: 88%

Effects of S24–7 on the weight of progeny rats after exposure to ceftriaxone sodium during pregnancy

et al. 2021

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Antibiotic exposure during pregnancy will adversely affect the growth of offspring; however, this remains controversial and the mechanism is poorly understood. To study this phenomenon, we added ceftriaxone sodium to the drinking water of pregnant rats and continuously monitored the body weight of their offspring. The results showed that compared with the control group, the offspring exposed to antibiotics during pregnancy had a higher body weight up to 3 weeks old but had a lower body weight at 6 weeks old. To determine the role of the gut microbiota and its metabolites in the growth of offspring, we collected feces for sequencing and further established that the experimental group has a different composition ratio of dominant bacteria at 6 week old, among which S24–7 correlated negatively with body weight and the metabolites that correlated with body weight-related unique flora were L-Valine, L-Leucine, Glutaric acid, N-Acetyl-L-glutamate, and 5-Methylcytosine. To further explore how they affect the growth of offspring, we submitted these data to Kyoto Encyclopedia of Genes and Genomes website for relevant pathway analysis. The results showed that compared with the control, the following metabolic pathways changed significantly: Valine, leucine, and isoleucine biosynthesis; Protein digestion and absorption; and Mineral absorption. Therefore, we believe that our findings support the conclusion that ceftriaxone sodium exposure in pregnancy has a long-lasting adverse effect on the growth of offspring because of an imbalance of gut microbiota, especially S24–7, via different metabolic pathways.

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Section: The Colonization Of Different Gut Microbiota Participate In Weight Changes Of Offspringsupporting

confidence: 88%

Effects of S24–7 on the weight of progeny rats after exposure to ceftriaxone sodium during pregnancy

et al. 2021

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“…It has been suggested that this difference may be caused by female ovarian hormones. Gender differences in intestinal microbiome in addition to microbiome difference between children with overweight/ obesity and children with healthy weight [35] may serve as an alternative explanation.…”

Section: Discussionmentioning

confidence: 99%

Higher prevalence of obesity among children with functional abdominal pain disorders

et al. 2020

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Background: Functional abdominal pain (FAP) disorders are one of the most common gastrointestinal disorders in children. We aimed to define the association between obesity and functional abdominal pain (FAP) disorders and to assess differences between overweight/obese children and normal weight children with FAP disorders. Methods: We conducted a retrospective study of children (2-18 years old) with a clinical diagnosis of FAP who were followed-up in our pediatric gastroenterology unit between 1/2016-10/2018. FAP disorders were defined according to the ROME IV criteria. Body mass index (BMI) percentiles were defined by CDC standards. Patients with BMIs ≥85th percentile were designated as being overweight/obese. A population control group was obtained from the 2015-2016 Israel national health survey. Results: Data from 173 children with FAP disorders (median age 11.5 years, 114 females) were included. Seventyone children (41%) were classified as having functional abdominal pain-NOS, 67 (38.7%) as having irritable bowel syndrome (IBS), and 35 (20.2%) has having functional dyspepsia. Fifty-three children (30.6%) were classified as being overweight/obese. Adolescents with FAP disorders had a significantly higher prevalence of overweight/obesity compared to controls (39.5% vs. 30%, respectively, p = 0.04). Children with FAP and overweight were older [12.4 (range 9.8-15.3) vs. 10.8 (7.4-14.1) years, p = 0.04] and had more hospitalizations due to FAP (20.8% vs. 7.6%, p = 0.01) compared to Children with FAP and normal weight. Conclusions: Adolescents with FAP had higher prevalence of overweight/obesity compared to controls. Future studies are warranted to raise awareness of weight issues in FAP and determine the effect of weight loss on FAP.

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“…25 In addition, the abundance and diversity of intestinal flora are reportedly negatively correlated with obesity. 26 Our results showed that the abundance of Bacteroides decreased; furthermore, obesity reduced the diversity of intestinal flora. The overall balance of the intestinal microflora is important in maintenance of homeostasis; 27 intestinal microflora are reportedly disordered in patients with obesity.…”

Section: Discussionmentioning

confidence: 50%

Leptin improves intestinal flora dysfunction in mice with high-fat diet-induced obesity

Shi

Xiong

et al. 2020

J Int Med Res

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Objective This study investigated the effects of leptin on intestinal flora and inflammation in mice with high-fat diet (HFD)-induced obesity. Methods Mice were fed an HFD for 8 weeks; some were concurrently administered oral leptin for 4 weeks. Pathological changes in adipose tissue were detected using hematoxylin–eosin staining; endotoxin content in adipose tissue was measured by enzyme-linked immunosorbent assay. Intestinal flora were characterized by 16S bacterial rDNA sequencing. Levels of Toll-like receptor 4 (TLR4), nuclear factor-κB inhibitor α (IκB-α), and phosphorylated c-Jun N-terminal kinase (p-JNK) were detected by western blotting. Results Mice in the HFD group exhibited weight gain, elevated endotoxin content, and adipocyte hypertrophy, compared with the non-obese control group. Moreover, abundance of bacteria in the Bacteroides genus and community diversity were both reduced in the HFD group; reductions also were observed at corresponding phylum, class, and order levels. Levels of TLR4, IκB-α, and p-JNK were also elevated in the HFD group. Compared with the model group, leptin administration reduced the weight gain and endotoxin content, while increasing Bacteroides abundance and community diversity; it also reduced the levels of TLR4, IκB-α, and p-JNK. Conclusion Leptin administration improved intestinal flora dysfunction and inflammation in mice with HFD-induced obesity.

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A study of the correlation between obesity and intestinal flora in school-age children

Cited by 45 publications

References 24 publications

Effects of S24–7 on the weight of progeny rats after exposure to ceftriaxone sodium during pregnancy

Effects of S24–7 on the weight of progeny rats after exposure to ceftriaxone sodium during pregnancy

Higher prevalence of obesity among children with functional abdominal pain disorders

Leptin improves intestinal flora dysfunction in mice with high-fat diet-induced obesity

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