A study of the composition of the alkaloids of Corydalis persica

Abstract

We have investigated Corydalis persica Cham et Schlecht, family Papaveraceae, the alkaloid composition of which has not been studied previously. From the tubers collected in the flowering phase (June 1, 1972) in the Bichinakskii Pass we isolated the combined alkaloids (1.63%) by the dichloroethane method. By column chromatography on alumina (activity grade I1) with elution by diethyl ether we obtained a white crystalline optically inactive substance with the composition C~0H15OsN , mp 266-267°C (ether) which was identified as sanguinarine [1]. Elution with diethyl ether-chloroform (97 : 3) gave chelerythrine, C21HlsOsN , mp 208°C (ether) [1]. Elution with diethyl ether-chloroform (95 : 5) gave a substance with the composition C20HlgOsN , mp 204-205°C, which was identical with an authentic sample of protopine [2]. 1o 2.

The Protopine Alkaloids

“…Typically, in TFA-J, C-5 appears at 25 ppm, C-6 at 56 ppm, C-8 at 59 ppm, 013 at 41 ppm and C-14 at 95 ppm, while the N-methyl carbon is near 46 ppm (131). (15) SOURCES: BERBERIDACEAE: Berberís (16) FUMARIACEAE: Corydalis (30,33,34,38,40,42,43,44,49,50,51,54,55,58,59,60,64,65,66,67,76,86,88,91,118,119,120,121) Dactylicapnos (61) Dicentra (38,52,56) Fumaria (1,29,47,57,68,69) P APA VE RACE AE: Argemone (2,25,26,114,115,116) Bocconia (103,122) Chelidonium (36,…”