A Study of the Coagulant Action of Eight Snake Venoms

Abstract

SummaryAn investigation of the eight coagulant snake venoms has revealed the presence in three of these of both a direct thrombin-like activity and the ability to produce a powerful prothrombin activator from factor X in the presence of phospholipid and factor V. The use of antivenom prepared against the venoms indicated that the active principles were antigenically distinct in the genera studied but that some species cross reaction occurred.

In vivo effects of Agkistrodon rhodostoma venom: studies with fibrinogen-131I.

“…3, 4, and 7), but those coinciding with the maximum of the peak could not be influenced. The same results were obtained with ARV, which is known not to be neutralized by normal serum antithrombin (21), as a clotting agent in system D. A remarkable feature of the virtually incoagulable samples (> 600 seconds) in systems B and C was that as early as 20 to 30 seconds after introducing the thrombin very fine fibers could be pulled out although no coherent fibrin network was visible.…”

Isotopic studies of therapeutic anticoagulation with a coagulating enzyme

“…The CE produces progressive depletion of the fibrinogen pool, probably through the formation of an atypical fibrin monomer differing from that produced by thrombin (1)(2)(3)(4)(5). Kinetic data obtained from animal experiments employing labeled fibrinogen indicate that fibrinogen depletion can, under optimal circumstances, proceed at exceptionally rapid rates, corresponding to half-times of 5-15 min (3,6,7).…”

Caracterização da ação inibitória da crotoxina sobre as funções de células endoteliais em matriz extracelular bidimensional e tridimensional. Estudos in vitro.

“…Além disso, em decorrência desta atividade neurotóxica é observada também insuficiência respiratória (AMARAL; MAGALHÃES; DE REZENDE, 1991;ROSENFELD, 1971). Além desta atividade, o veneno destas serpentes possui atividades miotóxica e coagulante (AZEVEDO-MARQUES et al, 1985;HERING, 1988;NAHAS;MACFARLANE;DENSON, 1964;ROSENFELD, 1971;), induzindo o quadro de rabdomiólise generalizada e incoagulabilidade (AZEVEDO-MARQUES; HERING, 1987;SANO-MARTINS et al, 2001). …”