A study of the chikungunya virus in humans in Turkey

Atalay, Tuğba; Kaygusuz, Sedat; Azkur, Ahmet Kürşat

doi:10.3906/sag-1604-36

Cited by 5 publications

(12 citation statements)

References 15 publications

(19 reference statements)

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“…The seroprevalence of CHIKV in adults was calculated based on 24 studies [ 3 , 15 – 36 ]. The pooled seroprevalence in this set of studies was 21% (95%CI 13–30), with high heterogeneity (I 2 = 99.5%; p < 0.00) observed in meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Chikungunya seroprevalence in population-based studies: a systematic review and meta-analysis

et al. 2023

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Background Seroprevalence studies about chikungunya infection are usually conducted after epidemics to estimate the magnitude of the attack. This study aimed to estimate the seroprevalence of CHIKV by WHO region, considering the periods of introduction of the virus in these regions and its potential to lead to epidemics. Methods We systematically reviewed Medline/Pubmed, Embase, Lilacs, Scopus and Web of Science for original articles published up to 2020. Cohort, case-control and cross-sectional studies were eligible for inclusion, based on the results of laboratory diagnosis of previous or previous and recent infection. Those conducted with symptomatic individuals were excluded. Results 596 articles were identified, 197 full-text were reviewed and 64 were included, resulting in 71 seroprevalences. Most were cross-sectional studies (92%), between 2001 and 2020 (92%), with population of all ages (55%), conducted in Kenya (10.9%), Brazil (9.4%) and French Polynesia (7.8%). The pooled estimates were 24% (95%CI 19–29; I2 = 99.7%; p < 0.00), being 21% (95%CI 13–30; I2 = 99.5%; p < 0.00) for adults, 7% (95%CI 0–23; I2 = 99.7%; p < 0.00) for children and 30% (95%CI 23–38; I2 = 99.7%; p < 0.00) for all ages. The higher seroprevalences were found in African, the Americas and South-East Asian Regions. Conclusions The great heterogeneity of seroprevalences points to the persistence of viral circulation. Even where the seroprevalence is high, the population replacement and the absence of vaccines mean that the risk of virus spread and epidemics remains. Registration PROSPERO CRD42020166227.

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Section: Resultsmentioning

confidence: 99%

Chikungunya seroprevalence in population-based studies: a systematic review and meta-analysis

et al. 2023

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“…The majority of the studies were exclusively conducted on dengue [ 15 – 112 ] (n = 123), with 16.% exclusively conducted on chikungunya (n = 29) [ 113 – 136 ] and 12% conducted on both dengue and chikungunya (n = 23) [ 137 – 154 ]; furthermore, seven studies were conducted on Zika [ 8 , 155 – 160 ], one study was conducted on both dengue and Zika [ 161 ] and two studies were conducted on both viruses [ 162 ].…”

Section: Resultsmentioning

confidence: 99%

“…Seroprevalence data are presented in Fig 6 . The seroprevalence of CHIKV ranged from 0.4% in a study sample of 500 blood donors from an urban area in Central Anatolia in Turkey [ 113 ] to 75.6% in a study conducted among 127 children living in an urban area in Haiti [ 142 ] and 76.0% in a study conducted among residents in French Polynesia [ 163 ]. Although only a small number of countries were represented worldwide, we noted that CHIKV seroprevalence was the highest among the general population of Lamu Island (Kenya) at 72% (95% confidence interval (CI): 69–79) [ 130 ]; among pregnant women in Thailand at 71.2% (95% CI: 52–84) [ 139 ] and among the general population of French Polynesia at 76% (95% CI: 71–81) [ 163 ], with both studies performing IgG ELISA; and among Haitian children at 75.6% (performing multiplex assay) [ 142 ] Variations within the same country were also observed in Kenya, where CHIKV seroprevalence varied substantially, between 1% and 72% [ 131 , 151 ].…”

Section: Resultsmentioning

confidence: 99%

Current challenges and implications for dengue, chikungunya and Zika seroprevalence studies worldwide: A scoping review

Fritzell¹,

Rousset²,

Adde³

et al. 2018

PLoS Negl Trop Dis

151

137

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BackgroundArboviral infections are a public health concern and an escalating problem worldwide. Estimating the burden of these diseases represents a major challenge that is complicated by the large number of unapparent infections, especially those of dengue fever. Serological surveys are thus required to identify the distribution of these diseases and measure their impact. Therefore, we undertook a scoping review of the literature to describe and summarize epidemiological practices, findings and insights related to seroprevalence studies of dengue, chikungunya and Zika virus, which have rapidly expanded across the globe in recent years.Methodology/Principal findingsRelevant studies were retrieved through a literature search of MEDLINE, WHOLIS, Lilacs, SciELO and Scopus (2000 to 2018). In total, 1389 publications were identified. Studies addressing the seroprevalence of dengue, chikungunya and/or Zika written in English or French and meeting the inclusion and exclusion criteria were included. In total, 147 studies were included, from which 185 data points were retrieved, as some studies used several different samples. Most of the studies were exclusively conducted on dengue (66.5%), but 16% were exclusively conducted on chikungunya, and 7 were exclusively conducted on Zika; the remainder were conducted on multiple arboviruses. A wide range of designs were applied, but most studies were conducted in the general population (39%) and in households (41%). Although several assays were used, enzyme-linked immunosorbent assays (ELISAs) were the predominant test used (77%). The temporal distribution of chikungunya studies followed the virus during its rapid expansion since 2004. The results revealed heterogeneity of arboviruses seroprevalence between continents and within a given country for dengue, chikungunya and Zika viruses, ranging from 0 to 100%, 76% and 73% respectively.Conclusions/SignificanceSerological surveys provide the most direct measurement for defining the immunity landscape for infectious diseases, but the methodology remains difficult to implement. Overall, dengue, chikungunya and Zika serosurveys followed the expansion of these arboviruses, but there remain gaps in their geographic distribution. This review addresses the challenges for researchers regarding study design biases. Moreover, the development of reliable, rapid and affordable diagnosis tools represents a significant issue concerning the ability of seroprevalence surveys to differentiate infections when multiple viruses co-circulate.

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“…In a study carried out by Kajeguka et al (12) in Tanzania on 1,100 individuals ranging from two to 70 years of age, IgG antibodies against CHIKV were found in 3.7%. In a recent study of testing the presence of the abovementioned virus using the Indirect Immunofluorescence test (IIFT) in 2017, Ataly et al (8) from Turkey reported a rate of 0.4% (two out of 500 serum samples from healthy people were positive). Based on the literature search, we found only one study from Iran carried out in 1974 by Saidi (13) on the prevalence of arboviruses in 100 children aged one to six years in the Caspian Sea area.…”

Section: Discussionmentioning

confidence: 99%

“…A cross-sectional study was performed on blood samples taken from children with the age range of one month to 14 years, attending the outpatient clinics of Mofid Children's Hospital in Tehran from March to December 2018. In this analytical descriptive study, the sample size of WNV was estimated at 11%, based on a study in Iran (7), while the sample size of CHIKV was estimated at 0.4% based on a study in Turkey (8). The sample size calculation was performed based on the confidence interval estimation using the Wilson score interval method with a type I error of 0.05 to obtain acceptable precision (9).…”

Section: Methodsmentioning

confidence: 99%

Seropositivity of Chikungunya and West Nile Viruses in Iranian Children in 2018

Solgi¹,

Karimi²,

Armin³

2020

Arch Pediatr Infect Dis

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Background: Several surveys have been conducted on the seroprevalence of viral infections caused by Chikungunya and West Nile viruses in humans. However, there is a paucity of studies on the seroprevalence and spread of these viruses in children. Objectives: We aimed to investigate the seropositivity of IgG antibodies against Chikungunya and West Nile viruses in a group of Iranian children aged one month to 14 years. Methods: A cross-sectional study was performed on blood samples collected from children aged one month to 14 years in Tehran who attended the outpatient clinics of a children’s hospital from March to December 2018. The serum IgG levels against Chikungunya and West Nile viruses were assessed using the ELISA technique. Results: Of 180 serum samples assessed for positivity, four (three from boys and one from girls) had positive IgG for Chikungunya and 11 (seven from boys and four from girls) had positive IgG for West Nile, causing overall seropositivity of 2.2% and 6.1% for Chikungunya and West Nile infections, respectively. Moreover, Chikungunya and West Nile viruses showed no significant association between seropositivity and sex. High seropositivity was observed predominantly in the age groups of below two years and over 10 years in Chikungunya and West Nile infections, respectively. However, the difference was not significant (P-value > 0.05). In the age group of one month to two years, all cases with positive IgG were less than six-month-old. Conclusions: The results of the seroprevalence of Chikungunya and West Nile viruses among children in Tehran showed the prevalence of these viral infections in this region. Therefore, these infections should be considered in the differential diagnosis for children with clinical symptoms of viral diseases.

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A study of the chikungunya virus in humans in Turkey

Cited by 5 publications

References 15 publications

Chikungunya seroprevalence in population-based studies: a systematic review and meta-analysis

Chikungunya seroprevalence in population-based studies: a systematic review and meta-analysis

Current challenges and implications for dengue, chikungunya and Zika seroprevalence studies worldwide: A scoping review

Seropositivity of Chikungunya and West Nile Viruses in Iranian Children in 2018

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