A study of the association of (Val66Met) polymorphism in the Brain-derived Neurotrophic Factor gene with alcohol dependence and extreme violence in Chinese males

Tsai, Shih‐Jen; Liao, Ding-Lieh; Yu, Younger W.‐Y.; Chen, Tai‐Jui; Wu, Hung‐Chi; Lin, Chun-Hui; Cheng, Chih‐Ya; Hong, Chen‐Jee

doi:10.1016/j.neulet.2005.02.043

Cited by 42 publications

(21 citation statements)

References 18 publications

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“…To our knowledge, this paper is the first to report a significant association between this gene and AUD. Two previous studies have investigated the association but have reported much smaller effect sizes and non-significant findings (Matsushita et al, 2004;Tsai et al, 2005). One of these, a Japanese case-control study, found no association with AUD, but did find that the met allele was associated with an earlier age of onset and increased violent behavior (Matsushita et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

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An investigation of associations between alcohol use disorder and polymorphisms on ALDH2, BDNF, 5‐HTTLPR, and MTHFR genes in older Korean men

Shin

Stewart

Ferri

et al. 2009

Int J Geriat Psychiatry

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AUD was associated with ALDH2*1 and BDNF met alleles in older Korean men. The first is consistent with previous research and likely to be explained by a protective effect of unpleasant symptoms following alcohol consumption associated with ALDH2*2. The second finding is novel and might be accounted for by BDNF-mediated serotonin or dopamine pathways. However, given the relatively small sample size, the results should be regarded as preliminary and requiring independent replication.

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Section: Discussionmentioning

confidence: 99%

“…This has been found to modify environmental risk of affective disorder (Kaufman et al, 2006;Kim et al, 2007). Only two studies, both negative, have investigated associations with AUD (Matsushita et al, 2004;Tsai et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

An investigation of associations between alcohol use disorder and polymorphisms on ALDH2, BDNF, 5‐HTTLPR, and MTHFR genes in older Korean men

Shin

Stewart

Ferri

et al. 2009

Int J Geriat Psychiatry

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show abstract

“…However, a smaller study involving 110 AD Chinese convicts with violent histories did not support an association of BDNF Val66Met with ASPD comorbidity. 30 Additional studies will be necessary in different clinical populations to determine if variation at NTRK2 is associated with ASPD itself, or may modify phenotypes that are comorbid with AD.…”

Section: Discussionmentioning

confidence: 99%

Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence

Anderson

Neyer

et al. 2007

Pharmacogenomics J

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To identify sequence variants in genes that may have roles in neuronal responses to alcohol, we resequenced the 5 0 region of tyrosine kinase B neurotrophin receptor gene (NTRK2) and determined linkage disequilibrium (LD) values, haplotype structure, and performed association analyses using 43 single nucleotide polymorphisms (SNPs) covering the entire NTRK2 region in a Finnish Caucasian sample of 229 alcohol-dependent subjects with antisocial personality disorder (ASPD) and 287 healthy controls. Individually, three SNPs were associated with alcohol dependence and alcohol abuse (AD) (P-value from 0.0019 to 0.0059, significance level was set at Pp0.01 corrected for multiple testing), whereas a common 18 locus haplotype within the largest LD block of NTRK2, a 119-kb region containing the 5 0 flanking region and exons 1-15, was marginally overrepresented in control subjects compared to AD individuals (global P ¼ 0.057). Taken together, these results support a role for the NTRK2 gene in addiction in a Caucasian population with AD and a subtype of ASPD.

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“…Excluded: no MDD phenotype, 8,14,67,68,[85][86][87][88][89][90][91][92][93][94][95][96][97] no case-control design, 22,31,[98][99][100][101][102][103] no adults 104,105 and no Hardy-Weinberg equilibrium (HWE). 106 Included: Caucasian studies, 11,[33][34][35][36][37][38][39][40] Asian studies 19,21,[41][42][43] and gender studies.…”

Section: Meta-regression Analysesmentioning

confidence: 99%

Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity

et al. 2008

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Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that has antidepressant-like effects in animals and may be implicated in the etiology of mood-related phenotypes. However, genetic association studies of the BDNF Val66Met polymorphism (single nucleotide polymorphism rs6265) in major depressive disorder (MDD) have produced inconsistent results. We conducted a meta-analysis of studies comparing the frequency of the BDNF Val66Met-coding variant in depressed cases (MDD) and nondepressed controls. A total of 14 studies involving 2812 cases with DSM-III or -IV defined MDD and 10 843 nondepressed controls met the inclusion criteria. Analyses were stratified either by gender or ethnicity (Asian and Caucasian) because MDD is more prevalent in women and in Caucasians and because BDNF allele frequencies differ by ethnicity. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were provided for allelic analyses (Met versus Val), as well as for genotypic analyses (Met/Met and Val/Met versus Val/Val). In the total sample, the BDNF Val66Met polymorphism was not significantly associated with depression. However, the gender stratified analyses revealed significant effects in both the allelic and genotypic analyses in men (OR MET , 95% CI; 1.27 (1.10-1.47); OR MET/MET , 95% CI; 1.67 (1.19-2.36)). Stratification according to ethnicity did not show significant effects of the Val66Met polymorphism on MDD. Our results suggest that the BDNF Val66Met polymorphism is of greater importance in the development of MDD in men than in women. Future research into gender issues will be of interest.

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A study of the association of (Val66Met) polymorphism in the Brain-derived Neurotrophic Factor gene with alcohol dependence and extreme violence in Chinese males

Cited by 42 publications

References 18 publications

An investigation of associations between alcohol use disorder and polymorphisms on ALDH2, BDNF, 5‐HTTLPR, and MTHFR genes in older Korean men

An investigation of associations between alcohol use disorder and polymorphisms on ALDH2, BDNF, 5‐HTTLPR, and MTHFR genes in older Korean men

Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence

Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity

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