A study of the antioxidant properties of Keggin-type polyoxometalates

Shan, Lei; Han, Yuexin; Li, Jiaxin; Li, Yao; Wang, Li; Chen, Bingnian; Li, Jian

doi:10.1039/d3dt01361h

Dalton Trans.

2023

DOI: 10.1039/d3dt01361h

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A study of the antioxidant properties of Keggin-type polyoxometalates

Lei Shan¹,

Yuexin Han²,

Jiaxin Li³

et al.

Abstract: In this paper, we used extracellular reactive oxygen radical scavenging assay and cellular antioxidant assay to investigate the antioxidant ability of Keggin-type polyoxometalates on the inside and outside of cells...

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2025

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Study on the regulatory mechanisms of mitochondrial biosynthesis by polyoxometalates

Lei,

Chen,

Wang

et al. 2025

Polyoxometalates

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In recent years, polyoxometalates have been systematically studied in the treatment of diabetes, tumor, cancer, inflammation and other diseases in vitro and in vivo, and their main therapeutic mechanisms are related to the generation of reactive oxygen species causing oxidative stress. The main site of reactive oxygen species production is the mitochondria, therefore, the mechanism of polyoxometalates treatment may be related to mitochondrial biosynthesis. This paper describes one of the mechanisms of polyoxometalates and diabetes mellitus, which involves the increase of reactive oxygen species, resulting in oxidative stress; at the same time, polyoxometalates have been preliminarily studied as antioxidants and antitumor in the treatment of diabetes mellitus and tumors, and the antioxidant and antitumor properties of polyoxometalates provide an additional possibility for the future as a therapeutic drug for disease treatment; on the basis of the study of oxidative stress and other biomolecule properties due to it, associating polyoxometalates as a mechanism of drug therapy actually closely related to mitochondria, through the study of polyoxometalates and mitochondrial biosynthesis regulation of the relationship between the mitochondria of its impact on the three aspects of the mitochondria, in order to provide a basis for the future in-depth study of the polyoxometalates of the role of drugs in the treatment of tumors, diabetes and other aspects.

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Study on the regulatory mechanisms of mitochondrial biosynthesis by polyoxometalates

Lei,

Chen,

Wang

et al. 2025

Polyoxometalates

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show abstract

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A study of the antioxidant properties of Keggin-type polyoxometalates

Abstract: In this paper, we used extracellular reactive oxygen radical scavenging assay and cellular antioxidant assay to investigate the antioxidant ability of Keggin-type polyoxometalates on the inside and outside of cells...

Cited by 1 publication

References 44 publications

Study on the regulatory mechanisms of mitochondrial biosynthesis by polyoxometalates

Study on the regulatory mechanisms of mitochondrial biosynthesis by polyoxometalates

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