1990
DOI: 10.1111/j.1346-8138.1990.tb01605.x
|View full text |Cite
|
Sign up to set email alerts
|

A Study of Systemic and Topical Effects of Topical Steroid Application through the Comparison of Two Application Schedules

Abstract: We compared two application schedules of a topical steroid, BV (Betamethasone valerate). The schedules were once daily and twice a week on juvenile Wistar rats treated for four weeks. Steroid actions were assessed topically (skin thickness and epidermal Langerhans cell density) and systemically (body weight and internal organ wet weights). The results revealed some rather severe systemic effects caused by frequent steroid application. And we also found a uniquely weak BV effect with Langerhans cells compared t… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2006
2006
2008
2008

Publication Types

Select...
1
1

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(1 citation statement)
references
References 27 publications
0
1
0
Order By: Relevance
“…Thus, continuous immunosuppression may be achieved by addressing complementary anti‐inflammatory pathways (97). Other strategies include intermittent use of the GC only every second day (tandem therapy) (98–100) or intermittent treatment twice a week (101,102) or use of very potent GCs only for a very few days with subsequent switch to compounds from weaker classes as soon as a response is observed (103,104).…”
Section: Strategies To Identify Gcs and Gc Like Drugs With A Reduced mentioning
confidence: 99%
“…Thus, continuous immunosuppression may be achieved by addressing complementary anti‐inflammatory pathways (97). Other strategies include intermittent use of the GC only every second day (tandem therapy) (98–100) or intermittent treatment twice a week (101,102) or use of very potent GCs only for a very few days with subsequent switch to compounds from weaker classes as soon as a response is observed (103,104).…”
Section: Strategies To Identify Gcs and Gc Like Drugs With A Reduced mentioning
confidence: 99%