2000
DOI: 10.1001/archopht.118.1.138
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A Study of Surgical Approaches to Retinal Vascular Occlusions

Abstract: To develop a surgical approach to retinal vascular occlusive diseases. Methods: Surgical manipulations were performed on the retinal vasculature to explore the feasibility of retinal vascular surgery. In a human cadaver eye model (25 procedures, 21 eyes), we performed (1) cannulations of retinal blood vessels with a flexible stylet and (2) arteriovenous sheathotomies. Histological findings were correlated with surgical outcomes. In an in vivo model (6 eyes, 5 animals), we examined the technical feasibility and… Show more

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Cited by 68 publications
(37 citation statements)
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“…These entities, the fact that a fair percentage of BRVO cases do not respond to laser photocoagulation [4], and the relatively limited functional gain of the BVO Study have led to the initiation of further search for new treatment modalities for macular edema in BRVO cases. Among these are the intravitreal injection of different concentrations of triamcinolone [5][6][7] or bevacizumab [8] and more invasive surgical approaches like cannulation of vein branches [9], arteriovenous branch sheathotomy [10], vitrectomy alone [11], and laser-induced formation of chorioretinal anastomoses [12]. Although results of several of these attempts seem to be promising, none has been subject of a randomized study report.…”
Section: Introductionmentioning
confidence: 99%
“…These entities, the fact that a fair percentage of BRVO cases do not respond to laser photocoagulation [4], and the relatively limited functional gain of the BVO Study have led to the initiation of further search for new treatment modalities for macular edema in BRVO cases. Among these are the intravitreal injection of different concentrations of triamcinolone [5][6][7] or bevacizumab [8] and more invasive surgical approaches like cannulation of vein branches [9], arteriovenous branch sheathotomy [10], vitrectomy alone [11], and laser-induced formation of chorioretinal anastomoses [12]. Although results of several of these attempts seem to be promising, none has been subject of a randomized study report.…”
Section: Introductionmentioning
confidence: 99%
“…branch retinal vein occlusion [4], but which has been found to be generally traumatic when performed with the instrumentation presently available [5]. Additional opportunities for performance improvement exist in otorhinolaryngological, neurological, and microvascular surgery [6].…”
mentioning
confidence: 99%
“…Surgical adhesion between the artery and vein at proximal arteriovenous crossings correlates with histopathologic findings of a common vascular wall observed in cases of branch retinal vein occlusion 16 and with studies of human cadaver eyes that underwent surgical manipulation of the retinal vasculature. 17 Conceivably, unless the conjoined vascular tissues are precisely divided, separation of the two vessels may result in a defect or tear in a vessel wall. No reports of complications relating to this aspect of surgical separation have yet been reported, despite many surgeries having been performed.…”
Section: Resultsmentioning
confidence: 99%