A Study of Some Anthraquinones of Rubia Cordifolia L. Incorporated Into Pinda Oil: An Ayurvedic Medicinal Oil Used for Topical Application in Dermatological and Inflammatory Conditions

Mahendra, Abeysekera Ajita; Bandara, Gunaherath Kamal; Chandanie, Ranasinghe; Lanka, Sri

doi:10.7897/2277-4343.05369

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…The treatment showed re-pigmentation in affected white patches and reduced symptoms, suggesting it could be a promising treatment approach (Ediriweera et al, 2009). It has also been reported that an Ayurvedic medicinal oil called "Bakuchi Oil" prepared from the dried fruits of Psoralea corylifolia L. (Fabaceae) which contains furanocoumarin and psoralen is used for the treatment of vitiligo in Sri Lanka (Abeysekera et al, 2012).…”

Section: Product Development By Natural Plant Materialsmentioning

confidence: 99%

Impact of herbal treatments for Vitiligo disease

Rathnayake,

Dahanayake

2024

UCR

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Vitiligo is a common skin disorder resulting from the breakdown of functional epidermal melanocytes. The global prevalence of vitiligo ranges from 0.5% to 2%, with higher rates reported in certain populations. Melanocytes, responsible for skin color, are destroyed in vitiligo condition leading to the appearance of smooth, white patches on the skin. The progression of vitiligo is influenced by various factors, including genetics, autoimmunity, psychosis, melanocyte self-destruction, trace element deficiency, oxidative stress, and other biochemical and environmental variables. Recent research has identified herbal plant extractions as potential agents for re-pigmentation and regeneration of normal skin color. Specific components of these herbal plants, such as furocoumarin, thymoquinone, flavonoids, curcuminoids, and glycyrrhizin, play crucial roles in promoting re-pigmentation. Combination therapies involving these herbal compounds have shown promise in increasing tyrosinase activity and reducing oxidative stress, which are two important aspects of vitiligo treatment. The review aims to comprehensively evaluate the efficacy of herbal plant therapies for melanocyte re-pigmentation in vitiligo patients. By analyzing the effectiveness of various herbal extracts and their active components, this study seeks to advance the understanding and potential application of herbal treatments for vitiligo. The findings from this review may contribute to the current knowledge on therapeutic options available for vitiligo patients.

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Section: Product Development By Natural Plant Materialsmentioning

confidence: 99%

Impact of herbal treatments for Vitiligo disease

Rathnayake,

Dahanayake

2024

UCR

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Larvicidal and Pupicidal Activities of Alizarin Isolated from Roots of Rubia cordifolia Against Culex quinquefasciatus Say and Aedes aegypti (L.) (Diptera: Culicidae)

et al. 2016

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The mosquitocidal activities of different fractions and a compound alizarin from the methanol extract of Rubia cordifolia roots were evaluated on larvae and pupae of Culex quinquefasciatus Say and Aedes aegypti (L.) (Diptera: Culicidae). Larvae and pupae were exposed to concentrations of 2.5, 5.0, 7.5 and 10 ppm for fractions and 0.5, 1.0, 1.5 and 2.0 ppm for compound. After 24 h, the mortality was assessed and the LC 50 and LC 90 values were estimated for larvae and pupae. Among the 23 fractions screened, fraction 2 from the methanol extract of R. cordifolia showed good mosquitocidal activity against C. quinquefasciatus and A. aegypti. LC 50 and LC 90 values of fraction 2 were 3.53 and 7.26 ppm for C. quinquefasciatus and 3.86 and 8.28 ppm for A. aegypti larvae, and 3.76 and 7.50 ppm for C. quinquefasciatus and 3.92 and 8.05 ppm for A. aegypti pupae, respectively. Further, the isolated compound alizarin presented good larvicidal and pupicidal activities. LC 50 and LC 90 values of alizarin for larvae were 0.81 and 3.86 ppm against C. quinquefasciatus and 1.31 and 6.04 ppm for A. aegypti larvae, respectively. Similarly, the LC 50 and LC 90 values of alizarin for pupae were 1.97 and 4.79 ppm for C. quinquefasciatus and 2.05 and 5.59 ppm for A. aegypti pupae, respectively. The structure of the isolated compound was identified on the basis of spectroscopic analysis and compared with reported spectral data. The results indicated that alizarin could be used as a potential larvicide and pupicide.

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In-vitro cell migration enhancing constituents from Decalepis hamiltonii , a plant used in the preparation of ‘Pinda oil’, a medicinal oil used in Ayurveda for wound management

Kulatunge,

Jayawardana,

Abeysekera

et al. 2024

Natural Product Research

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Decalepis hamiltonii, Wight & Arn. (Apocyanaceae) is a one of the raw materials used in the preparation of 'Pinda oil', a medicinal oil which is used for treatment of wounds in Ayurveda. Of the hexanes, dichloromethane, and ethyl acetate extracts derived from the plant raw materials used to prepare Pinda oil, the hexanes extract of D. hamiltonii exhibited the highest mean percentage wound closure (75.1 ± 2.9) compared to the negative controls (1% DMSO in DMEM, 4.2 ± 1.2 and 100% DMEM, 4.1 ± 0.9) in the scratch wound assay (SWA). Fractionation of the hexanes extract of stem of D. hamiltonii led to the isolation of 2-hydroxy-4-methoxybenzaldehyde (1) and a mixture of long chain esters of lupeol (2), which showed enhanced cell migration in SWA. It was observed that the esters of lupeol bind to the cell membrane and/or enter the cells during the SWA. It was found that these constituents are also present in 'Pinda oil' which may contribute to the enhancement of wound healing activity of 'Pinda oil'. Experimental General Experimental procedureSolvents used for the chemical extraction were of either analytical grade or general-purpose reagent grade purified by fractional distillation at the boiling point of the solvent. Chemicals and reagents were purchased from Merck, Sigma-Aldrich, Fluka, Himedia and Invitrogen.Column chromatography was carried out using Silica gel G (Fluka 60741) as the stationary phase. Fractions obtained from the column chromatography were combined according to their

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A Study of Some Anthraquinones of Rubia Cordifolia L. Incorporated Into Pinda Oil: An Ayurvedic Medicinal Oil Used for Topical Application in Dermatological and Inflammatory Conditions

Cited by 3 publications

References 7 publications

Impact of herbal treatments for Vitiligo disease

Impact of herbal treatments for Vitiligo disease

Larvicidal and Pupicidal Activities of Alizarin Isolated from Roots of Rubia cordifolia Against Culex quinquefasciatus Say and Aedes aegypti (L.) (Diptera: Culicidae)

In-vitro cell migration enhancing constituents from Decalepis hamiltonii , a plant used in the preparation of ‘Pinda oil’, a medicinal oil used in Ayurveda for wound management

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