A study of serum nitric oxide levels in psoriasis

Gokhale, Neeta R; Belgaumkar, Vasudha Abhijit; Pandit, D; Deshpande, Shantanu; Damle, Dhananjay K

doi:10.4103/0378-6323.16232

Cited by 24 publications

(33 citation statements)

References 11 publications

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“…Our results demonstrating significantly increased NO levels in plasma of active psoriatic patients seem to be in agreement with literature data [9,10]. Decreasing but still significantly higher NO plasma levels after 3 weeks of effective treatment suggest that the balance in NO metabolism has not been restored yet.…”

supporting

confidence: 93%

“…Gokhale et al [9] demonstrated significantly increased mean serum NO level in 36 patients presenting different types of psoriasis (chronic, erythrodermic, pustular) and found significantly higher NO levels in patients with active disease as compared to normal individuals. Örem et al [10] observed low NO serum levels during the inactive phase in psoriatic patients (mean PASI 1.7).…”

mentioning

confidence: 97%

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Nitric oxide levels in plasma and fibroblast cultures of psoriasis vulgaris patients

Zalewska

Wyczółkowska²,

Sysa-Jędrzejowska³

2007

Journal of Dermatological Science

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supporting

confidence: 93%

mentioning

confidence: 97%

Nitric oxide levels in plasma and fibroblast cultures of psoriasis vulgaris patients

Zalewska

Wyczółkowska²,

Sysa-Jędrzejowska³

2007

Journal of Dermatological Science

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“…Some authors have reported improvement of the Ps plaque with the topical application of NO-donors [1] while others found the opposite effect [23]. Significantly increased nitrite/nitrate levels were found in plasma of patients with Ps and, furthermore, these levels showed a positive correlation with PASI score [9].…”

Section: Discussionmentioning

confidence: 97%

“…A few studies also determined the levels of nitrite and nitrate (two NO metabolites) in blood samples of Ps patients [9,24,28]. Nitrite/nitrate levels were significantly increased in plasma of Ps patients compared to healthy control and showed a positive correlation with PASI score [9], and a significant reduction of the metabolite levels after treatment with metothrexate has also been reported [28].…”

Section: Introductionmentioning

confidence: 97%

Influence of endothelial nitric oxide synthase polymorphisms in psoriasis risk

et al. 2011

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Abstract:Nitric oxide (NO) is a potent regulator of keratinocyte growth and differentiation that has been implicated in the pathogenesis of psoriasis (Ps). The NOS3 -786 T/C (SNP id rs2070744; www.ensembl.org ), intron 4 variable number tandem repeat (VNTR), and Glu298Asp (SNP id rs1799983) polymorphisms, have been associated with differences in NO plasma concentrations and with the risk of hypertension (HT) and ischemic cardiac disease (IC). The aim of this study was to determine whether the above mentioned NOS3 variants contributed to the risk of Ps, and were associated with the risk for HT and CAD in these patients. A total of 368 patients with chronic plaque Ps and 400 healthy controls were genotyped for the NOS3 -786 T/C, intron 4 VNTR, and Glu298Asp polymorphisms. Carriers of the -786 C allele were significantly more frequent among the patients (p<0.001). Carriers of the 4-repeats allele (45+44 genotypes) were also more frequent a (p<0.001). No significant difference was found for the Glu298Asp polymorphism. None of the NOS3 variants was associated with Ht and CAD in our population. In conclusion, NOS3 gene polymorphism would be risk factors for developing Ps.

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“…It was reported that levels were significantly higher in the patients group. Moreover, in the chronic plaque group NO levels increased with the duration of the disease [51]. Serum levels of NO in normal controls, psoriatic patients prior to, and after treatment with methotrexate were compared.…”

Section: Innate Immune Response a Cells And Their Receptors 1 Rementioning

confidence: 99%

Factors involved in the pathogenesis of psoriasis

Abdelnoor¹,

Al-Akl²

2013

asms

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Psoriasis is thought to be an autoimmune disease. Both innate and adaptive immune factors are involved in pathogenesis. Innate immune factors include neutrophils, dendritic cells, mast cells and keratinocytes as well as receptors that they express and cytokines they produce, and the coagulation and complement systems. The adaptive immune factors include mainly the T-lymphocyte subsets and their cytokines. Cytokines produced in both arms of the immune response and appear to play a major role in pathogenesis are TNF and IL-17. Innate and adaptive immune responses are interdependent and this review covers both arms of the immune response with respect to what is known about the pathogenesis of psoriasis. Keywords: innate immunity, adaptive immunity, TNF, IL-17Psoriasis is a chronic inflammation of the skin. Several types have been defined based on clinical grounds. They include guttate, plaque, inverse, pustular, erythrodermic,

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A study of serum nitric oxide levels in psoriasis

Abstract: Nitric oxide levels were significantly increased in patients with psoriasis and these levels showed a positive correlation with severity and duration in the chronic plaque type group.

Cited by 24 publications

References 11 publications

Nitric oxide levels in plasma and fibroblast cultures of psoriasis vulgaris patients

Nitric oxide levels in plasma and fibroblast cultures of psoriasis vulgaris patients

Influence of endothelial nitric oxide synthase polymorphisms in psoriasis risk

Factors involved in the pathogenesis of psoriasis

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