A study of serum IgG4 levels in the clinical metamorphosis of autoimmune thyroid disease

Thewjitcharoen, Yotsapon; Krittiyawong, Sirinate; Porramatikul, Sriurai; Wanothayaroj, Ekgaluck; Lekpittaya, Nampetch; Jeamjiraprasert, Jirapat; Nakasatien, Soontaree; Himathongkam, Thep

doi:10.1016/j.jcte.2017.05.002

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…Our pooled analyses showed that IgG4 levels were significantly elevated in RA patients (35.98%) compared to the frequencies reported in healthy individuals. Various studies have found that the frequency of elevated IgG4 in healthy subjects ranged from 0-2.5% [19,31]. In keeping with our findings, several studies have reported higher frequencies of elevated IgG4 in autoimmune diseases such as Sjogren syndrome, systemic lupus erythematosus, myasthenia gravis, and eosinophilic granulomatous polyangiitis [32,33].…”

Section: Discussionsupporting

confidence: 91%

Frequency and Clinical Significance of Elevated IgG4 in Rheumatoid Arthritis: A Systematic Review

2022

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Immunoglobulin (Ig)G4 is a unique protein molecule and its role in autoimmune diseases remains elusive and controversial. Accumulating evidence suggests a pathogenic role of IgG4 in rheumatoid arthritis (RA). Rheumatoid factors (RF) in RA can recognize the Fc domains of IgG4 to form RF-IgG4 immune complexes that may activate the complement system leading to synovial injury. The aim of this article was to systematically review the literature from the past 2 decades to determine the frequency of elevated IgG4 and its clinical significance in RA. We comprehensively searched the Pubmed, Scopus, and Web of Science databases with the following terms: “IgG4”, “rheumatoid arthritis”, and “immunoglobulin G4”, and scrutinized all of the relevant publications. Based on the selection criteria, 12 studies were incorporated, which involved a total of 1715 RA patients. Out of 328 subjects from three studies, the pooled frequency of elevated non-specific IgG4 was 35.98%. There was a significant positive correlation between the IgG4 levels and the RA disease activity based on DAS-28 measurements (r = 0.245–0.253) and inflammatory markers, i.e., erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels (r = 0.262–0.389). Longitudinal studies that measured the serial levels of IgG4 consistently showed a decline in the concentrations (up to 48% less than baseline) with disease modifying anti-rheumatic drug (DMARD) treatment. Current evidence suggests that serum IgG4 levels are significantly elevated in RA compared to the general population. This review indicates that IgG4 is a promising biomarker of disease activity and tends to decline in response to DMARD therapies. Biologic therapies have revolutionized the therapeutic armamentarium of RA in the recent decade, and IgG4 appears to be a potential treatment target.

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Section: Discussionsupporting

confidence: 91%

Frequency and Clinical Significance of Elevated IgG4 in Rheumatoid Arthritis: A Systematic Review

2022

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“…The main cause of clinical hyperthyroidism and hypothyroidism is GD and HT, respectively [1, 4]. Hyperthyroidism in GD is attributed to thyroid-stimulating autoantibodies to the TSH receptor, whereas hypothyroidism in HT is related to autoantibodies against thyroid peroxidase and thyroglobulin [5]. The pathogenesis of AITD is thought to be the interaction between susceptibility genes and environmental factors.…”

Section: Introductionmentioning

confidence: 99%

IRF7 Gene Variations Confer Susceptibility to Autoimmune Thyroid Diseases and Graves’ Ophthalmopathy

Yao

Zhang

et al. 2019

International Journal of Endocrinology

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The objective of this study was to investigate whether IRF7 polymorphisms are associated with autoimmune thyroid diseases (AITDs). We selected three single nucleotide polymorphisms (SNPs) of IRF7, namely, rs1061501, rs1131665, and rs1061502 for genotyping using PCR-based ligase detection reaction (LDR) method in a total of 1659 participants (592 with Graves' disease, 297 with Hashimoto's thyroiditis, and 770 healthy controls). Gene-disease and genotype-clinical phenotype associations were evaluated for the three SNPs. Our results showed that the AG genotype and the minor allele G frequency of rs1131665 and rs1061502 in AITD patients were both higher than those of the controls (rs1131665: AG genotype: P = 0.017, OR = 1.968; allele G: P = 0.018, OR = 1.946; rs1061502: AG genotype: P = 0.029, OR = 1.866; allele G: P = 0.031, OR = 1.847). Subgroup analysis also showed that the AG genotype and the minor allele G frequency of rs1131665 and rs1061502 in Graves' disease patients were both higher than those of the controls (rs1131665: AG genotype: P = 0.015, OR = 2.074; allele G: P = 0.016, OR = 2.048; rs1061502: AG genotype: P = 0.034, OR = 1.919; allele G: P = 0.035, OR = 1.898). Furthermore, the allele G frequency of rs1061501 was associated with Graves' ophthalmopathy (P = 0.035, OR = 1.396). No significant difference in IRF7 polymorphisms was found between Hashimoto's thyroiditis patients and controls. Our study has revealed for the first time that IRF7 is a susceptibility gene for AITD, especially for Graves' disease and Graves' ophthalmopathy.

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A study of serum IgG4 levels in the clinical metamorphosis of autoimmune thyroid disease

Cited by 2 publications

References 33 publications

Frequency and Clinical Significance of Elevated IgG4 in Rheumatoid Arthritis: A Systematic Review

Frequency and Clinical Significance of Elevated IgG4 in Rheumatoid Arthritis: A Systematic Review

IRF7 Gene Variations Confer Susceptibility to Autoimmune Thyroid Diseases and Graves’ Ophthalmopathy

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