A Study of Serum Fat Globules in Atherosclerotic and Non-Atherosclerotic Male Subjects

Lipid Metabolism and the Effect of a Combined Lipotropic Agent††

“…, by the hepatic reticulo‐endothelial cells. He further states that, in view of this new data plus the fact that experimentally induced atherosclerosis depends upon the absorption of dietary cholesterol, it would perhaps be wise not to dismiss the findings of Moreton (15), Becker, Meyer and Necheles (20), Zinn and Griffith (21), and Block, Barker and Mann (22) or the concepts of Hueper (16) and Hirsch and Weishouse (32). The possible relationship of hyperchylomicronemia to atherosclerosis, although not proved, offers an opportunity for productive research.…”

“…Zinn and Griffith (21) and Labecki (24) noted a correlation between elevated chylomicron levels and the incidence of myocardial infarction. Our main interest, however, is not to establish a relationship between a high chylomicron‐lipomicron ratio and atherosclerosis, but to establish the effect of a certain combination of lipotropic agents upon the chylomicron level.…”

“…Friedman states that Moreton (15), sensing that chylomicra contained cholesterol, emphasized that abnormal persistence of this aggregate in the blood was the essential cause of atherosclerosis in man. It is of interest that Becker, Meyer and Necheles (20), as well as Zinn and Griffith (21), have presented evidence which strongly suggests that there is an abnormally slow disappearance of such chylomicra, both with advancing age and in atherosclerosis. Block, Barker and Mann (22) also gave indirect and partial support to Moreton's concept, for they observed a reduction in the clearing mechanism of atherosclerotic individuals; such clearing is equivalent to the dissolution of large macro‐molecular aggregates or chylomicra.…”

Coronary Artery Disease

“…Lipid particles, known as chylomicrons, which appear in the plasma after meals, are not significantly different in normal and atherosclerotic individuals (Zinn and Griffith, 1950), but they remain for a longer period with increasing age (Becker, Meyer and Necheles, 1949). They are more numerous in hyper-cholesterolremia (Moreton, 1947).…”